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@ARTICLE{Lutz:292291,
      author       = {M. Lutz and C. S. Aigner and S. Flassbeck and F. Krueger
                      and C. G. F. Gatefait and C. Kolbitsch and B. Silemek and F.
                      Seifert and T. Schaeffter and S. Schmitter$^*$},
      title        = {{B}1-{MRF}: {L}arge dynamic range {MRF}-based absolute {B}
                      1 + mapping in the human body at 7{T}.},
      journal      = {Magnetic resonance in medicine},
      volume       = {92},
      number       = {6},
      issn         = {1522-2594},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2024-01652},
      pages        = {2473-2490},
      year         = {2024},
      note         = {#LA:E020#/ 2024 Dec;92(6):2473-2490},
      abstract     = {This study aims to map the transmit magnetic field ( B 1 +
                      $$ {B}_1^{+} $$ ) in the human body at 7T using MR
                      fingerprinting (MRF), with a focus on achieving high
                      accuracy and precision across a large dynamic range,
                      particularly at low flip angles (FAs).A FLASH-based MRF
                      sequence (B1-MRF) with high B 1 + $$ {B}_1^{+} $$
                      sensitivity was developed. Phantom and in vivo abdominal
                      imaging were performed at 7T, and the results were compared
                      with established reference methods, including a slow but
                      precise preparation-based method (PEX), saturated TurboFLASH
                      (satTFL), actual flip angle imaging (AFI) and Bloch-Siegert
                      shift (BSS).The MRF signal curve was highly sensitive to B 1
                      + $$ {B}_1^{+} $$ , while T1 sensitivity was comparatively
                      low. The phantom experiment showed good agreement of B 1 +
                      $$ {B}_1^{+} $$ to PEX for a T1 range of 204-1691 ms
                      evaluated at FAs from 0° to 70°. Compared to the
                      references, a dynamic range increase larger than a factor of
                      two was determined experimentally. In vivo liver scans
                      showed a strong correlation between B1-MRF, satTFL, and
                      RPE-AFI in a low body mass index (BMI) subject (18.1 kg/m2).
                      However, in larger BMI subjects (≥25.5 kg/m2),
                      inconsistencies were observed in low B 1 + $$ {B}_1^{+} $$
                      regions for satTFL and RPE-AFI, while B1-MRF still provided
                      consistent results in these regions.B1-MRF provides accurate
                      and precise B 1 + $$ {B}_1^{+} $$ maps over a wide range of
                      FAs, surpassing the capabilities of existing methods in the
                      FA range < 60°. Its enhanced sensitivity at low FAs is
                      advantageous for various applications requiring precise B 1
                      + $$ {B}_1^{+} $$ estimates, potentially advancing the
                      frontiers of ultra-high field (UHF) body imaging at 7T and
                      beyond.},
      keywords     = {B 1 + $$ {B}_1^{+} $$ mapping (Other) / 7 Tesla (Other) /
                      MRF (Other) / body MRI (Other) / ultrahigh field MRI
                      (Other)},
      cin          = {E020},
      ddc          = {610},
      cid          = {I:(DE-He78)E020-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39133639},
      doi          = {10.1002/mrm.30242},
      url          = {https://inrepo02.dkfz.de/record/292291},
}