Home > Publications database > B1-MRF: Large dynamic range MRF-based absolute B 1 + mapping in the human body at 7T. > print

001     292291
005     20250731110944.0
024 7 _ |a 10.1002/mrm.30242
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024 7 _ |a 0740-3194
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037 _ _ |a DKFZ-2024-01652
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Lutz, Max
|0 0009-0001-1956-3757
|b 0
245 _ _ |a B1-MRF: Large dynamic range MRF-based absolute B 1 + mapping in the human body at 7T.
260 _ _ |a New York, NY [u.a.]
|c 2024
|b Wiley-Liss
336 7 _ |a article
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500 _ _ |a #LA:E020#/ 2024 Dec;92(6):2473-2490
520 _ _ |a This study aims to map the transmit magnetic field ( B 1 + $$ {B}_1^{+} $$ ) in the human body at 7T using MR fingerprinting (MRF), with a focus on achieving high accuracy and precision across a large dynamic range, particularly at low flip angles (FAs).A FLASH-based MRF sequence (B1-MRF) with high B 1 + $$ {B}_1^{+} $$ sensitivity was developed. Phantom and in vivo abdominal imaging were performed at 7T, and the results were compared with established reference methods, including a slow but precise preparation-based method (PEX), saturated TurboFLASH (satTFL), actual flip angle imaging (AFI) and Bloch-Siegert shift (BSS).The MRF signal curve was highly sensitive to B 1 + $$ {B}_1^{+} $$ , while T1 sensitivity was comparatively low. The phantom experiment showed good agreement of B 1 + $$ {B}_1^{+} $$ to PEX for a T1 range of 204-1691 ms evaluated at FAs from 0° to 70°. Compared to the references, a dynamic range increase larger than a factor of two was determined experimentally. In vivo liver scans showed a strong correlation between B1-MRF, satTFL, and RPE-AFI in a low body mass index (BMI) subject (18.1 kg/m2). However, in larger BMI subjects (≥25.5 kg/m2), inconsistencies were observed in low B 1 + $$ {B}_1^{+} $$ regions for satTFL and RPE-AFI, while B1-MRF still provided consistent results in these regions.B1-MRF provides accurate and precise B 1 + $$ {B}_1^{+} $$ maps over a wide range of FAs, surpassing the capabilities of existing methods in the FA range < 60°. Its enhanced sensitivity at low FAs is advantageous for various applications requiring precise B 1 + $$ {B}_1^{+} $$ estimates, potentially advancing the frontiers of ultra-high field (UHF) body imaging at 7T and beyond.
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650 _ 7 |a B 1 + $$ {B}_1^{+} $$ mapping
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650 _ 7 |a 7 Tesla
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650 _ 7 |a MRF
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650 _ 7 |a body MRI
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650 _ 7 |a ultrahigh field MRI
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700 1 _ |a Aigner, Christoph Stefan
|0 0000-0003-3618-9610
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700 1 _ |a Flassbeck, Sebastian
|b 2
700 1 _ |a Krueger, Felix
|0 0000-0001-9453-8992
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700 1 _ |a Gatefait, Constance G F
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700 1 _ |a Kolbitsch, Christoph
|0 0000-0002-4355-8368
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700 1 _ |a Silemek, Berk
|0 0000-0001-8227-3632
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700 1 _ |a Seifert, Frank
|0 0000-0002-7065-2528
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700 1 _ |a Schaeffter, Tobias
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700 1 _ |a Schmitter, Sebastian
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773 _ _ |a 10.1002/mrm.30242
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