% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{CamilleriRobles:292331,
      author       = {C. Camilleri-Robles and R. Amador and M. Tiebe$^*$ and A.
                      Teleman$^*$ and F. Serras and R. Guigó and M. Corominas},
      title        = {{L}ong non-coding {RNA}s involved in {D}rosophila
                      development and regeneration.},
      journal      = {NAR: genomics and bioinformatics},
      volume       = {6},
      number       = {3},
      issn         = {2631-9268},
      address      = {Oxford},
      publisher    = {Oxford University Press},
      reportid     = {DKFZ-2024-01682},
      pages        = {lqae091},
      year         = {2024},
      abstract     = {The discovery of functional long non-coding RNAs (lncRNAs)
                      changed their initial concept as transcriptional noise.
                      LncRNAs have been identified as regulators of multiple
                      biological processes, including chromatin structure, gene
                      expression, splicing, mRNA degradation, and translation.
                      However, functional studies of lncRNAs are hindered by the
                      usual lack of phenotypes upon deletion or inhibition. Here,
                      we used Drosophila imaginal discs as a model system to
                      identify lncRNAs involved in development and regeneration.
                      We examined a subset of lncRNAs expressed in the wing, leg,
                      and eye disc development. Additionally, we analyzed
                      transcriptomic data from regenerating wing discs to profile
                      the expression pattern of lncRNAs during tissue repair. We
                      focused on the lncRNA CR40469, which is upregulated during
                      regeneration. We generated CR40469 mutant flies that
                      developed normally but showed impaired wing regeneration
                      upon cell death induction. The ability of these mutants to
                      regenerate was restored by the ectopic expression of
                      CR40469. Furthermore, we found that the lncRNA CR34335 has a
                      high degree of sequence similarity with CR40469 and can
                      partially compensate for its function during regeneration in
                      the absence of CR40469. Our findings point to a potential
                      role of the lncRNA CR40469 in trans during the response to
                      damage in the wing imaginal disc.},
      cin          = {B140},
      ddc          = {570},
      cid          = {I:(DE-He78)B140-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39157585},
      pmc          = {pmc:PMC11327875},
      doi          = {10.1093/nargab/lqae091},
      url          = {https://inrepo02.dkfz.de/record/292331},
}