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000292339 0247_ $$2doi$$a10.1002/mrm.30258
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000292339 1001_ $$0P:(DE-He78)43cd90a720198a8170a0d26d7fac0c11$$aAwenius, Marcel$$b0$$eFirst author$$udkfz
000292339 245__ $$aThree-dimensional radial echo-planar spectroscopic imaging for hyperpolarized 13C MRSI in vivo.
000292339 260__ $$aNew York, NY [u.a.]$$bWiley-Liss$$c2024
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000292339 500__ $$a#EA:E020#LA:E020# / 2025 Jan;93(1):31-41
000292339 520__ $$aTo demonstrate the feasibility of 3D echo-planar spectroscopic imaging (EPSI) technique with rapid volumetric radial k-space sampling for hyperpolarized (HP) 13C magnetic resonance spectroscopic imaging (MRSI) in vivo.A radial EPSI (rEPSI) was implemented on a 3 T clinical PET/MR system. To enable volumetric coverage, the sinusoidal shaped readout gradients per k-t-spoke were rotated along the three spatial dimensions in a golden-angle like manner. A distance-weighted, density-compensated gridding reconstruction was used, also in cases with undersampling of spokes in k-space. Measurements without and with HP 13C-labeled substances were performed in phantoms and rats using a double-resonant 13C/1H volume resonator with 72 mm inner diameter.Phantom measurements demonstrated the feasibility of the implemented rEPSI sequence, as well as the robustness to undersampling in k-space up to a factor of 5 without advanced reconstruction techniques. Applied to measurements with HP [1-13C]pyruvate in a tumor-bearing rat, we obtained well-resolved MRSI datasets with a large matrix size of 123 voxels covering the whole imaging FOV of (180 mm)3 within 6.3 s, enabling to observe metabolism in dynamic acquisitions.After further optimization, the proposed rEPSI method may be useful in applications of HP 13C-tracers where unknown or varying metabolite resonances are expected, and the acquisition of dynamic, volumetric MRSI datasets with an adequate temporal resolution is a challenge.
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000292339 650_7 $$2Other$$a13C MRSI
000292339 650_7 $$2Other$$adynamic nuclear polarization
000292339 650_7 $$2Other$$aecho‐planar
000292339 650_7 $$2Other$$ahyperpolarization
000292339 650_7 $$2Other$$aradial
000292339 7001_ $$0P:(DE-He78)0139525f1446c07e385f5c96ba8fb3c2$$aAbeln, Helen$$b1$$udkfz
000292339 7001_ $$0P:(DE-He78)48203a26384a5ea951cd117124881d23$$aMüller, Melanie$$b2$$udkfz
000292339 7001_ $$0P:(DE-He78)aa7c5ddf01ae4204a9724ad52583db88$$aFranke, Vanessa$$b3$$udkfz
000292339 7001_ $$0P:(DE-He78)3522253bb6e5869f0ded8481c4687390$$aRincon, Gino$$b4$$udkfz
000292339 7001_ $$0P:(DE-He78)06ec1253cfc102aebeeb536a65133370$$aGlowa, Christin$$b5$$udkfz
000292339 7001_ $$0P:(DE-He78)457f9335c8acb3df17ab056995cebbf9$$aSchmitt, Michaela$$b6$$udkfz
000292339 7001_ $$0P:(DE-He78)de58687f353ef277d45cecfc7c6c45ff$$aBangert, Renate$$b7$$udkfz
000292339 7001_ $$0P:(DE-He78)a31009717cfc3a58addc3ad92b3636b2$$aLudwig, Dominik$$b8
000292339 7001_ $$0P:(DE-He78)17e270765cb79a4a3b19014bbb1095bb$$aSchmidt, Andreas$$b9$$udkfz
000292339 7001_ $$0P:(DE-He78)59dfdd0ee0a7f0db81535f0781a3a6d6$$aKuder, Tristan Anselm$$b10$$udkfz
000292339 7001_ $$0P:(DE-He78)022611a2317e4de40fd912e0a72293a8$$aLadd, Mark$$b11$$udkfz
000292339 7001_ $$0P:(DE-He78)29b2f01310f7022916255ddba2750f9b$$aBachert, Peter$$b12$$udkfz
000292339 7001_ $$0P:(DE-He78)247915c007544e1293ff21b939b16214$$aBiegger, Philipp$$b13$$udkfz
000292339 7001_ $$0P:(DE-He78)577a5c61f44b8023e229610afbc7cd4e$$aKorzowski, Andreas$$b14$$eLast author$$udkfz
000292339 773__ $$0PERI:(DE-600)1493786-4$$a10.1002/mrm.30258$$n1$$p31-41$$tMagnetic resonance in medicine$$v93$$x1522-2594$$y2024
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