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@ARTICLE{Awenius:292339,
      author       = {M. Awenius$^*$ and H. Abeln$^*$ and M. Müller$^*$ and V.
                      Franke$^*$ and G. Rincon$^*$ and C. Glowa$^*$ and M.
                      Schmitt$^*$ and R. Bangert$^*$ and D. Ludwig$^*$ and A.
                      Schmidt$^*$ and T. A. Kuder$^*$ and M. Ladd$^*$ and P.
                      Bachert$^*$ and P. Biegger$^*$ and A. Korzowski$^*$},
      title        = {{T}hree-dimensional radial echo-planar spectroscopic
                      imaging for hyperpolarized 13{C} {MRSI} in vivo.},
      journal      = {Magnetic resonance in medicine},
      volume       = {93},
      number       = {1},
      issn         = {1522-2594},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2024-01690},
      pages        = {31-41},
      year         = {2024},
      note         = {#EA:E020#LA:E020# / 2025 Jan;93(1):31-41},
      abstract     = {To demonstrate the feasibility of 3D echo-planar
                      spectroscopic imaging (EPSI) technique with rapid volumetric
                      radial k-space sampling for hyperpolarized (HP) 13C magnetic
                      resonance spectroscopic imaging (MRSI) in vivo.A radial EPSI
                      (rEPSI) was implemented on a 3 T clinical PET/MR system. To
                      enable volumetric coverage, the sinusoidal shaped readout
                      gradients per k-t-spoke were rotated along the three spatial
                      dimensions in a golden-angle like manner. A
                      distance-weighted, density-compensated gridding
                      reconstruction was used, also in cases with undersampling of
                      spokes in k-space. Measurements without and with HP
                      13C-labeled substances were performed in phantoms and rats
                      using a double-resonant 13C/1H volume resonator with 72 mm
                      inner diameter.Phantom measurements demonstrated the
                      feasibility of the implemented rEPSI sequence, as well as
                      the robustness to undersampling in k-space up to a factor of
                      5 without advanced reconstruction techniques. Applied to
                      measurements with HP [1-13C]pyruvate in a tumor-bearing rat,
                      we obtained well-resolved MRSI datasets with a large matrix
                      size of 123 voxels covering the whole imaging FOV of (180
                      mm)3 within 6.3 s, enabling to observe metabolism in dynamic
                      acquisitions.After further optimization, the proposed rEPSI
                      method may be useful in applications of HP 13C-tracers where
                      unknown or varying metabolite resonances are expected, and
                      the acquisition of dynamic, volumetric MRSI datasets with an
                      adequate temporal resolution is a challenge.},
      keywords     = {13C MRSI (Other) / dynamic nuclear polarization (Other) /
                      echo‐planar (Other) / hyperpolarization (Other) / radial
                      (Other)},
      cin          = {E020 / HD01 / E040 / FR01},
      ddc          = {610},
      cid          = {I:(DE-He78)E020-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)E040-20160331 / I:(DE-He78)FR01-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39164797},
      doi          = {10.1002/mrm.30258},
      url          = {https://inrepo02.dkfz.de/record/292339},
}