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000292341 0247_ $$2doi$$a10.1016/j.ejrad.2024.111679
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000292341 041__ $$aEnglish
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000292341 1001_ $$0P:(DE-He78)eba11eff7c9c475da132d5343d569759$$aMascalchi, Mario$$b0$$eFirst author
000292341 245__ $$aLarge cell carcinoma of the lung: LDCT features and survival in screen-detected cases.
000292341 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2024
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000292341 520__ $$aTo investigate the early radiological features and survival of Large Cell Carcinoma (LCC) cases diagnosed in low-dose computed tomography (LDCT) screening trials.Two radiologists jointly reviewed the radiological features of screen-detected LCCs observed in NLST, ITALUNG, and LUSI trials between 2002 and 2016, comprising a total of 29,744 subjects who underwent 3-5 annual screening LDCT examinations. Survival or causes of death were established according to the mortality registries extending more than 12 years since randomization.LCC was diagnosed in 30 (4 %) of 750 subjects with screen-detected lung cancer (LC), including 15 prevalent and 15 incident cases. Three additional LCCs occurred as interval cancers during the screening period. LDCT images were available for 29 cases of screen-detected LCCs, and 28 showed a single, peripheral, and well-defined solid nodule or mass with regularly smooth (39 %), lobulated (43 %), or spiculated (18 %) margins. One case presented as hilar mass. In 9 incident LCCs, smaller solid nodules were identified in prior LDCT examinations, allowing us to calculate a mean Volume Doubling Time (VDT) of 98.7 ± 47.8 days. The overall five-year survival rate was 50 %, with a significant (p = 0.0001) difference between stages I-II (75 % alive) and stages III-IV (10 % alive).LCC is a fast-growing neoplasm that can escape detection by annual LDCT screening. LCC typically presents as a single solid peripheral nodule or mass, often with lobulated margins, and exhibits a short VDT. The 5-year survival reflects the stage at diagnosis.
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000292341 650_7 $$2Other$$aITALUNG
000292341 650_7 $$2Other$$aLUSI
000292341 650_7 $$2Other$$aLarge cell carcinoma
000292341 650_7 $$2Other$$aLow dose CT
000292341 650_7 $$2Other$$aLung cancer
000292341 650_7 $$2Other$$aNLST
000292341 650_7 $$2Other$$aScreening
000292341 650_7 $$2Other$$aSurvival
000292341 7001_ $$aPuliti, Donella$$b1
000292341 7001_ $$aCavigli, Edoardo$$b2
000292341 7001_ $$0P:(DE-HGF)0$$aCortés-Ibáñez, Francisco O$$b3
000292341 7001_ $$aPicozzi, Giulia$$b4
000292341 7001_ $$aCarrozzi, Laura$$b5
000292341 7001_ $$aGorini, Giuseppe$$b6
000292341 7001_ $$0P:(DE-He78)3e76653311420a51a5faeb80363bd73e$$aDelorme, Stefan$$b7$$udkfz
000292341 7001_ $$aZompatori, Maurizio$$b8
000292341 7001_ $$aRaffaella De Luca, Giulia$$b9
000292341 7001_ $$aDiciotti, Stefano$$b10
000292341 7001_ $$aEva Comin, Camilla$$b11
000292341 7001_ $$aAlì, Greta$$b12
000292341 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b13$$eLast author$$udkfz
000292341 773__ $$0PERI:(DE-600)2005350-2$$a10.1016/j.ejrad.2024.111679$$gVol. 179$$p111679$$tEuropean journal of radiology$$v179$$x0720-048X$$y2024
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