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@ARTICLE{Mascalchi:292341,
      author       = {M. Mascalchi$^*$ and D. Puliti and E. Cavigli and F. O.
                      Cortés-Ibáñez$^*$ and G. Picozzi and L. Carrozzi and G.
                      Gorini and S. Delorme$^*$ and M. Zompatori and G. Raffaella
                      De Luca and S. Diciotti and C. Eva Comin and G. Alì and R.
                      Kaaks$^*$},
      title        = {{L}arge cell carcinoma of the lung: {LDCT} features and
                      survival in screen-detected cases.},
      journal      = {European journal of radiology},
      volume       = {179},
      issn         = {0720-048X},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2024-01692},
      pages        = {111679},
      year         = {2024},
      note         = {#EA:C020#LA:C020#},
      abstract     = {To investigate the early radiological features and survival
                      of Large Cell Carcinoma (LCC) cases diagnosed in low-dose
                      computed tomography (LDCT) screening trials.Two radiologists
                      jointly reviewed the radiological features of
                      screen-detected LCCs observed in NLST, ITALUNG, and LUSI
                      trials between 2002 and 2016, comprising a total of 29,744
                      subjects who underwent 3-5 annual screening LDCT
                      examinations. Survival or causes of death were established
                      according to the mortality registries extending more than 12
                      years since randomization.LCC was diagnosed in 30 (4 $\%)$
                      of 750 subjects with screen-detected lung cancer (LC),
                      including 15 prevalent and 15 incident cases. Three
                      additional LCCs occurred as interval cancers during the
                      screening period. LDCT images were available for 29 cases of
                      screen-detected LCCs, and 28 showed a single, peripheral,
                      and well-defined solid nodule or mass with regularly smooth
                      (39 $\%),$ lobulated (43 $\%),$ or spiculated (18 $\%)$
                      margins. One case presented as hilar mass. In 9 incident
                      LCCs, smaller solid nodules were identified in prior LDCT
                      examinations, allowing us to calculate a mean Volume
                      Doubling Time (VDT) of 98.7 ± 47.8 days. The overall
                      five-year survival rate was 50 $\%,$ with a significant (p =
                      0.0001) difference between stages I-II (75 $\%$ alive) and
                      stages III-IV (10 $\%$ alive).LCC is a fast-growing neoplasm
                      that can escape detection by annual LDCT screening. LCC
                      typically presents as a single solid peripheral nodule or
                      mass, often with lobulated margins, and exhibits a short
                      VDT. The 5-year survival reflects the stage at diagnosis.},
      keywords     = {ITALUNG (Other) / LUSI (Other) / Large cell carcinoma
                      (Other) / Low dose CT (Other) / Lung cancer (Other) / NLST
                      (Other) / Screening (Other) / Survival (Other)},
      cin          = {C020 / E010},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331 / I:(DE-He78)E010-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39163805},
      doi          = {10.1016/j.ejrad.2024.111679},
      url          = {https://inrepo02.dkfz.de/record/292341},
}