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@ARTICLE{Huybrechts:292355,
      author       = {I. Huybrechts and B. Chimera and G. T. Hanley-Cook and C.
                      Biessy and M. Deschasaux-Tanguy and M. Touvier and E.
                      Kesse-Guyot and B. Srour and J. Baudry and J. Berlivet and
                      C. Casagrande and G. Nicolas and J. B. Lopez and C. J.
                      Millett and E. K. Cakmak and O. J. K. Robinson and K. A.
                      Murray and M. B. Schulze and G. Masala and M. Guevara and S.
                      Bodén and A. J. Cross and K. Tsilidis and A. K. Heath and
                      S. Panico and P. Amiano and J. M. Huerta and T. Key and U.
                      Ericson and T. Stocks and M. W. Lundblad and G. Skeie and C.
                      Sacerdote and V. Katzke$^*$ and M. C. Playdon and P. Ferrari
                      and P. Vineis and C. Lachat and M. J. Gunter},
      title        = {{F}ood biodiversity and gastrointestinal cancer risk in
                      nine {E}uropean countries: {A}nalysis within a prospective
                      cohort study.},
      journal      = {European journal of cancer},
      volume       = {210},
      issn         = {0014-2964},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2024-01704},
      pages        = {114258},
      year         = {2024},
      abstract     = {Food biodiversity in human diets has potential co-benefits
                      for both public health and sustainable food systems.
                      However, current evidence on the potential relationship
                      between food biodiversity and cancer risk, and particularly
                      gastrointestinal cancers typically related to diet, remains
                      limited. This study evaluated how dietary species richness
                      (DSR) was associated with gastrointestinal cancer risk in a
                      pan-European population.Associations between DSR and
                      subsequent gastrointestinal cancer risk were examined among
                      450,111 adults enrolled in the European Prospective
                      Investigation into Cancer and Nutrition cohort (EPIC,
                      initiated in 1992), free of cancer at baseline. Usual
                      dietary intakes were assessed at recruitment with
                      country-specific dietary questionnaires. DSR of an
                      individual's yearly diet was calculated based on the
                      absolute number of unique biological species in each food
                      and drink item. Associations between DSR and cancer risk
                      were assessed by multivariable Cox proportional hazards
                      regression models.During a median follow-up time of 14.1
                      years (SD=3.9), 10,705 participants were diagnosed with
                      gastrointestinal cancer. Hazard ratios (HRs) and 95 $\%$
                      confidence intervals (CIs) comparing overall
                      gastrointestinal cancer risk in the highest versus lowest
                      quintiles of DSR indicated inverse associations in
                      multivariable-adjusted models [HR (95 $\%$ CI): 0.77
                      (0.69-0.87); P-value < 0·0001] (Table 2). Specifically,
                      inverse associations were observed between DSR and
                      oesophageal squamous cell carcinoma, proximal colon,
                      colorectal, and liver cancer risk (p-trend<0.05 for all
                      cancer types).Greater food biodiversity in the diet may
                      lower the risk of certain gastrointestinal cancers. Further
                      research is needed to replicate these novel findings and to
                      understand potential mechanisms.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39168001},
      doi          = {10.1016/j.ejca.2024.114258},
      url          = {https://inrepo02.dkfz.de/record/292355},
}