TY  - JOUR
AU  - Obrecht-Sturm, Denise
AU  - Schoof, Melanie
AU  - Eckhardt, Alicia
AU  - Mynarek, Martin
AU  - Gilbert, Mark R
AU  - Aldape, Kenneth
AU  - Armstrong, Terri S
AU  - Ramaswamy, Vijay
AU  - Bockmayr, Michael
AU  - von Hoff, Katja
AU  - Fleischhack, Gudrun
AU  - Adolph, Jonas E
AU  - Tippelt, Stephan
AU  - Pfister, Stefan
AU  - Pajtler, Kristian
AU  - Sturm, Dominik
AU  - Drexler, Richard
AU  - Ricklefs, Franz L
AU  - Stepien, Natalia
AU  - Gojo, Johannes
AU  - Pietsch, Torsten
AU  - Warmuth-Metz, Monika
AU  - Kortmann, Rolf
AU  - Timmermann, Beate
AU  - Haberler, Christine
AU  - Rutkowski, Stefan
AU  - Schüller, Ulrich
TI  - Distinct relapse pattern across molecular ependymoma types.
JO  - Neuro-Oncology
VL  - 27
IS  - 1
SN  - 1522-8517
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DKFZ-2024-01709
SP  - 267–276
PY  - 2025
N1  -  Volume 27, Issue 1, January 2025, Pages 267–276
AB  - Ependymoma (EPN) is not a uniform disease but represents different disease types with biological and clinical heterogeneity. However, the pattern of when and where different types of EPN relapse is not yet comprehensively described.We assembled 269 relapsed intracranial EPN from pediatric (n=233) and adult (n=36) patients from European and Northern American cohorts and correlated DNA methylation patterns and copy-number alterations with clinical information.The cohort comprised the following molecular EPN types: PF-EPN-A (n=177), ST-EPN-ZFTA (n=45), PF-EPN-B (n=31), PF-EPN-SE (n=12), and ST-EPN-YAP (n=4). First relapses of PF-EPN-B (PF: posterior-fossa) and PF-EPN-SE (SE: subependymoma) occurred later than of PF-EPN-A, ST-EPN-YAP (ST: supratentorial), or ST-EPN-ZFTA (median time to relapse: 4.3 and 6.0 years vs. 1.9/1.0/2.4 years; p<0.01). Metastatic or combined recurrences in PF-EPN-B and -A more often involved the spinal cord than in ST-EPN-ZFTA (72.7
KW  - ependymoma (Other)
KW  - metastatic (Other)
KW  - recurrence (Other)
KW  - relapse (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39171767
DO  - DOI:10.1093/neuonc/noae166
UR  - https://inrepo02.dkfz.de/record/292426
ER  -