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@ARTICLE{Cariolou:292457,
      author       = {M. Cariolou and S. Christakoudi and M. J. Gunter and T. Key
                      and A. Pérez-Cornago and R. Travis and R. Zamora-Ros and K.
                      E. T. Petersen and A. Tjønneland and E. Weiderpass and R.
                      Kaaks$^*$ and P. Seibold$^*$ and E. Inan-Eroglu and M. B.
                      Schulze and G. Masala and C. Agnoli and R. Tumino and C. Di
                      Girolamo and A. Aizpurua and M. Rodriguez-Barranco and C.
                      Santiuste and M. Guevara and D. Aune and D. S. Chan and D.
                      C. Muller and K. K. Tsilidis},
      title        = {{A}diposity assessed close to diagnosis and prostate cancer
                      prognosis in the {EPIC} study.},
      journal      = {JNCI cancer spectrum},
      volume       = {8},
      number       = {5},
      issn         = {2515-5091},
      address      = {Oxford},
      publisher    = {Oxford University Press},
      reportid     = {DKFZ-2024-01724},
      pages        = {pkae070},
      year         = {2024},
      note         = {2024 Sep 2;8(5):pkae070},
      abstract     = {Adiposity has been characterised as a modifiable risk
                      factor of prostate cancer. Its association with outcomes
                      after prostate cancer diagnosis, however, needs to be better
                      understood and obtain more evidence to assist the
                      development of lifestyle guidance for prostate cancer
                      patients.We investigated the associations between adiposity
                      indices close to prostate cancer diagnosis (up to two years
                      pre- or up to five years post-diagnosis) and mortality in
                      1,968 men of the European Prospective Investigation into
                      Cancer and Nutrition (EPIC) cohort. Men were followed for a
                      median of 9.5 years. Cox proportional-hazards models were
                      adjusted for age and year of diagnosis, stage, grade,
                      smoking and stratified by country.Each 5-unit increment in
                      pre- or post-diagnosis body mass index (BMI) combined was
                      associated with a $30\%$ higher rate of all-cause and a
                      $49\%$ higher rate of prostate cancer-specific mortality.
                      Similarly, each 5-unit increment in pre-diagnosis BMI was
                      associated with a $35\%$ higher rate of all-cause and a
                      $51\%$ higher rate of prostate cancer-specific mortality.
                      The associations were less strong for post-diagnosis BMI
                      with a lower number of men in analyses. Less clear positive
                      associations were shown for waist circumference, hip
                      circumference, and waist-to-hip ratio but data was
                      limited.Elevated levels of adiposity close to prostate
                      cancer diagnosis could lead to higher risk of mortality;
                      therefore, men are encouraged to maintain a healthy weight.
                      Additional research is needed to confirm if excessive
                      adiposity after prostate cancer diagnosis could worsen
                      prognosis.},
      keywords     = {adiposity (Other) / lifestyle (Other) / mortality (Other) /
                      prostate cancer (Other) / survival (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39180334},
      doi          = {10.1093/jncics/pkae070},
      url          = {https://inrepo02.dkfz.de/record/292457},
}