% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Koedijk:292501,
      author       = {J. B. Koedijk and I. van der Werf and L. Penter$^*$ and M.
                      A. Vermeulen and F. Barneh and A. Perzolli and J. I.
                      Meesters-Ensing and D. S. Metselaar$^*$ and T. Margaritis
                      and M. Fiocco and H. A. de Groot-Kruseman and R. Moeniralam
                      and K. Bang Christensen and B. Porter and K. Pfaff and J. S.
                      Garcia and S. J. Rodig and C. J. Wu and H. Hasle and S.
                      Nierkens and M. E. Belderbos and C. M. Zwaan and O.
                      Heidenreich},
      title        = {{A} multidimensional analysis reveals distinct immune
                      phenotypes and the composition of immune aggregates in
                      pediatric acute myeloid leukemia.},
      journal      = {Leukemia},
      volume       = {38},
      number       = {11},
      issn         = {0887-6924},
      address      = {London},
      publisher    = {Springer Nature},
      reportid     = {DKFZ-2024-01748},
      pages        = {2332-2343},
      year         = {2024},
      note         = {2024 Nov;38(11):2332-2343},
      abstract     = {Because of the low mutational burden and consequently,
                      fewer potential neoantigens, children with acute myeloid
                      leukemia (AML) are thought to have a T cell-depleted or
                      'cold' tumor microenvironment and may have a low likelihood
                      of response to T cell-directed immunotherapies.
                      Understanding the composition, phenotype, and spatial
                      organization of T cells and other microenvironmental
                      populations in the pediatric AML bone marrow (BM) is
                      essential for informing future immunotherapeutic trials
                      about targetable immune-evasion mechanisms specific to
                      pediatric AML. Here, we conducted a multidimensional
                      analysis of the tumor immune microenvironment in pediatric
                      AML and non-leukemic controls. We demonstrated that nearly
                      one-third of pediatric AML cases has an immune-infiltrated
                      BM, which is characterized by a decreased ratio of M2- to
                      M1-like macrophages. Furthermore, we detected the presence
                      of large T cell networks, both with and without colocalizing
                      B cells, in the BM and dissected the cellular composition of
                      T- and B cell-rich aggregates using spatial transcriptomics.
                      These analyses revealed that these aggregates are hotspots
                      of CD8+ T cells, memory B cells, plasma cells and/or
                      plasmablasts, and M1-like macrophages. Collectively, our
                      study provides a multidimensional characterization of the BM
                      immune microenvironment in pediatric AML and indicates
                      starting points for further investigations into
                      immunomodulatory mechanisms in this devastating disease.},
      cin          = {B062 / HD01 / BE01},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)BE01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39187578},
      doi          = {10.1038/s41375-024-02381-w},
      url          = {https://inrepo02.dkfz.de/record/292501},
}