% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Janke:292528,
      author       = {F. Janke$^*$ and F. Stritzke$^*$ and K. Dvornikovich and H.
                      Franke and A. K. Angeles$^*$ and A. L. Riediger$^*$ and S.
                      Ogrodnik$^*$ and S. Gerhardt$^*$ and S. Regnery and P.
                      Schröter and L. Bauer and K. Weusthof and M. Görtz$^*$ and
                      S. Harrabi$^*$ and K. Herfarth$^*$ and C. Neelsen$^*$ and D.
                      Paech$^*$ and H.-P. Schlemmer$^*$ and A. Abdollahi$^*$ and
                      S. Adeberg$^*$ and J. Debus$^*$ and H. Sültmann$^*$ and T.
                      Held$^*$},
      title        = {{E}arly circulating tumor {DNA} changes predict outcomes in
                      head and neck cancer patients under re-radiotherapy.},
      journal      = {International journal of cancer},
      volume       = {156},
      number       = {4},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2024-01774},
      pages        = {853-864},
      year         = {2025},
      note         = {#EA:B063#EA:E050#LA:B063#LA:E050# / 2025 Feb
                      15;156(4):853-864},
      abstract     = {Local recurrence after radiotherapy is common in locally
                      advanced head and neck cancer (HNC) patients. Re-irradiation
                      can improve local disease control, but disease progression
                      remains frequent. Hence, predictive biomarkers are needed to
                      adapt treatment intensity to the patient's individual risk.
                      We quantified circulating tumor DNA (ctDNA) in sequential
                      plasma samples and correlated ctDNA levels with disease
                      outcome. Ninety four longitudinal plasma samples from 16
                      locally advanced HNC patients and 57 healthy donors were
                      collected at re-radiotherapy baseline, after 5 and 10
                      radiation fractions, at irradiation end, and at routine
                      follow-up visits. Plasma DNA was subjected to low coverage
                      whole genome sequencing for copy number variation (CNV)
                      profiling to quantify ctDNA burden. CNV-based ctDNA burden
                      was detected in 8/16 patients and 25/94 plasma samples. Ten
                      additional ctDNA-positive samples were identified by
                      tracking patient-specific CNVs found in earlier sequential
                      plasma samples. ctDNA-positivity after 5 and 10 radiation
                      fractions (both: log-rank, p = .050) as well as at the end
                      of irradiation correlated with short progression-free
                      survival (log-rank, p = .006). Moreover, a pronounced
                      decrease of ctDNA toward re-radiotherapy termination was
                      associated with worse treatment outcome (log-rank, p =
                      .005). Dynamic ctDNA tracking in serial plasma beyond
                      re-radiotherapy reflected treatment response and imminent
                      disease progression. In five patients, molecular progression
                      was detected prior to tumor progression based on clinical
                      imaging. Our findings emphasize that quantifying ctDNA
                      during re-radiotherapy may contribute to disease monitoring
                      and personalization of adjuvant treatment, follow-up
                      intervals, and dose prescription.},
      keywords     = {circulating tumor DNA (Other) / copy number variations
                      (Other) / head and neck cancer (Other) / predictive
                      biomarker (Other) / re‐radiotherapy (Other)},
      cin          = {B063 / E250 / E050 / E210 / HD01 / E010},
      ddc          = {610},
      cid          = {I:(DE-He78)B063-20160331 / I:(DE-He78)E250-20160331 /
                      I:(DE-He78)E050-20160331 / I:(DE-He78)E210-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)E010-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39212345},
      doi          = {10.1002/ijc.35152},
      url          = {https://inrepo02.dkfz.de/record/292528},
}