TY  - JOUR
AU  - Winter, Ruth
AU  - Amghar, Mariam
AU  - Wacker, Anja S
AU  - Bakos, Gabor
AU  - Tas, Harun
AU  - Roscher, Mareike
AU  - Kelly, James M
AU  - Benesova-Schäfer, Martina
TI  - Future Treatment Strategies for Cancer Patients Combining Targeted Alpha Therapy with Pillars of Cancer Treatment: External Beam Radiation Therapy, Checkpoint Inhibition Immunotherapy, Cytostatic Chemotherapy, and Brachytherapy.
JO  - Pharmaceuticals
VL  - 17
IS  - 8
SN  - 1424-8247
CY  - Basel
PB  - MDPI
M1  - DKFZ-2024-01784
SP  - 1031
PY  - 2024
N1  - #EA:E270#LA:E270#
AB  - Cancer is one of the most complex and challenging human diseases, with rising incidences and cancer-related deaths despite improved diagnosis and personalized treatment options. Targeted alpha therapy (TαT) offers an exciting strategy emerging for cancer treatment which has proven effective even in patients with advanced metastatic disease that has become resistant to other treatments. Yet, in many cases, more sophisticated strategies are needed to stall disease progression and overcome resistance to TαT. The combination of two or more therapies which have historically been used as stand-alone treatments is an approach that has been pursued in recent years. This review aims to provide an overview on TαT and the four main pillars of therapeutic strategies in cancer management, namely external beam radiation therapy (EBRT), immunotherapy with checkpoint inhibitors (ICI), cytostatic chemotherapy (CCT), and brachytherapy (BT), and to discuss their potential use in combination with TαT. A brief description of each therapy is followed by a review of known biological aspects and state-of-the-art treatment practices. The emphasis, however, is given to the motivation for combination with TαT as well as the pre-clinical and clinical studies conducted to date.
KW  - alpha-emitters (Other)
KW  - brachytherapy (Other)
KW  - checkpoint inhibitors (Other)
KW  - combination therapy (Other)
KW  - cytostatic chemotherapy (Other)
KW  - external beam radiation therapy (Other)
KW  - immunotherapy (Other)
KW  - pre-clinical and clinical studies (Other)
KW  - targeted alpha therapy (Other)
KW  - targeted radionuclide therapy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39204136
C2  - pmc:PMC11359268
DO  - DOI:10.3390/ph17081031
UR  - https://inrepo02.dkfz.de/record/292541
ER  -