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@ARTICLE{deVrieze:292542,
      author       = {M. de Vrieze$^*$ and R. Al-Monajjed$^*$ and M. Boschheidgen
                      and P. Albers$^*$},
      title        = {{P}rostate {C}ancer {S}creening in {Y}oung {M}en.},
      journal      = {Journal of Personalized Medicine},
      volume       = {14},
      number       = {8},
      issn         = {2075-4426},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2024-01785},
      pages        = {818},
      year         = {2024},
      note         = {#EA:C130#LA:C130#},
      abstract     = {Background: Prostate cancer (PCa) screening strategies are
                      being developed and evaluated in several countries. However,
                      most of the evidence regarding PCa screening has been
                      generated in study populations aged 50 and older. Aims: This
                      study summarizes findings of a screening trial in younger
                      men and discuss those findings in the context of other
                      screening trials. Methods: Non-systematic review. Results:
                      Screening of 45-year-old men resulted in a low PCa detection
                      rate. Nonetheless, almost $70\%$ of screen-detected PCa at
                      this age was clinically significant. In young men ISUP GG 1
                      screen-detected cancers warrant rigorous follow-up. A
                      baseline, midlife prostate-specific antigen (PSA) value at
                      age 45 may safely exclude the vast majority of men from
                      further screening investigations for at least 5 years. At
                      age 45, a confirmatory PSA value reduces the number of
                      subsequent tests almost by half. Sequential magnetic
                      resonance imaging (MRI) as a reflex test subsequent to an
                      elevated PSA ≥ 3 ng/mL needs further investigation in
                      young men. Conclusions: Screening in young men needs to be
                      carefully investigated in order to avoid overscreening and
                      overdiagnosis.},
      subtyp        = {Review Article},
      keywords     = {PSA (Other) / baseline PSA (Other) / multiparametric MRI
                      (Other) / prostate cancer (Other) / prostate cancer
                      screening (Other) / risk-adapted screening (Other)},
      cin          = {C130},
      ddc          = {610},
      cid          = {I:(DE-He78)C130-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39202010},
      pmc          = {pmc:PMC11355119},
      doi          = {10.3390/jpm14080818},
      url          = {https://inrepo02.dkfz.de/record/292542},
}