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000292544 1001_ $$0P:(DE-He78)9de098e657ace4132ad97f1c1a688826$$aJiang, Xiangli$$b0$$eFirst author
000292544 245__ $$aP53-dependent hypusination of eIF5A affects mitochondrial translation and senescence immune surveillance.
000292544 260__ $$a[London]$$bNature Publishing Group UK$$c2024
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000292544 520__ $$aCellular senescence is characterized by a permanent growth arrest and is associated with tissue aging and cancer. Senescent cells secrete a number of different cytokines referred to as the senescence-associated secretory phenotype (SASP), which impacts the surrounding tissue and immune response. Here, we find that senescent cells exhibit higher rates of protein synthesis compared to proliferating cells and identify eIF5A as a crucial regulator of this process. Polyamine metabolism and hypusination of eIF5A play a pivotal role in sustaining elevated levels of protein synthesis in senescent cells. Mechanistically, we identify a p53-dependent program in senescent cells that maintains hypusination levels of eIF5A. Finally, we demonstrate that functional eIF5A is required for synthesizing mitochondrial ribosomal proteins and monitoring the immune clearance of premalignant senescent cells in vivo. Our findings establish an important role of protein synthesis during cellular senescence and suggest a link between eIF5A, polyamine metabolism, and senescence immune surveillance.
000292544 536__ $$0G:(DE-HGF)POF4-312$$a312 - Funktionelle und strukturelle Genomforschung (POF4-312)$$cPOF4-312$$fPOF IV$$x0
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000292544 650_7 $$2NLM Chemicals$$aPeptide Initiation Factors
000292544 650_7 $$2NLM Chemicals$$aEukaryotic Translation Initiation Factor 5A
000292544 650_7 $$2NLM Chemicals$$aTumor Suppressor Protein p53
000292544 650_7 $$2NLM Chemicals$$aRNA-Binding Proteins
000292544 650_7 $$2NLM Chemicals$$aPolyamines
000292544 650_7 $$2NLM Chemicals$$aRibosomal Proteins
000292544 650_7 $$03874VXF092$$2NLM Chemicals$$ahypusine
000292544 650_7 $$0K3Z4F929H6$$2NLM Chemicals$$aLysine
000292544 650_2 $$2MeSH$$aPeptide Initiation Factors: metabolism
000292544 650_2 $$2MeSH$$aPeptide Initiation Factors: genetics
000292544 650_2 $$2MeSH$$aEukaryotic Translation Initiation Factor 5A
000292544 650_2 $$2MeSH$$aCellular Senescence
000292544 650_2 $$2MeSH$$aTumor Suppressor Protein p53: metabolism
000292544 650_2 $$2MeSH$$aRNA-Binding Proteins: metabolism
000292544 650_2 $$2MeSH$$aRNA-Binding Proteins: genetics
000292544 650_2 $$2MeSH$$aHumans
000292544 650_2 $$2MeSH$$aProtein Biosynthesis
000292544 650_2 $$2MeSH$$aMitochondria: metabolism
000292544 650_2 $$2MeSH$$aAnimals
000292544 650_2 $$2MeSH$$aMice
000292544 650_2 $$2MeSH$$aImmunologic Surveillance
000292544 650_2 $$2MeSH$$aPolyamines: metabolism
000292544 650_2 $$2MeSH$$aRibosomal Proteins: metabolism
000292544 650_2 $$2MeSH$$aRibosomal Proteins: genetics
000292544 650_2 $$2MeSH$$aLysine: metabolism
000292544 650_2 $$2MeSH$$aLysine: analogs & derivatives
000292544 7001_ $$0P:(DE-He78)9bae5e495cd17da99206bde0a310a87e$$aBaig, Ali Hyder$$b1$$eFirst author
000292544 7001_ $$0P:(DE-He78)739e39176c0b4e701c9ae425485c2912$$aPalazzo, Giuliana$$b2$$udkfz
000292544 7001_ $$0P:(DE-He78)5944c192df14d8441fa71121b91b96d9$$aDel Pizzo, Rossella$$b3$$udkfz
000292544 7001_ $$0P:(DE-He78)da6fb7085973e134322e03d63b6d2028$$aBortecen, Toman$$b4$$udkfz
000292544 7001_ $$00000-0002-1339-7647$$aGroessl, Sven$$b5
000292544 7001_ $$00000-0001-9890-7345$$aZaal, Esther A$$b6
000292544 7001_ $$0P:(DE-He78)1f71ccf4137962d5dbf12200b9ffa75d$$aAmaya Ramirez, Cinthia Claudia$$b7$$udkfz
000292544 7001_ $$0P:(DE-He78)de7b14bf7f622d35c8dabed808304bc9$$aKowar, Alexander$$b8$$udkfz
000292544 7001_ $$0P:(DE-HGF)0$$aAviles-Huerta, Daniela$$b9
000292544 7001_ $$00000-0003-0746-8565$$aBerkers, Celia R$$b10
000292544 7001_ $$0P:(DE-He78)c8525dbb77cddc5280375ea4a5e3c13e$$aPalm, Wilhelm$$b11$$udkfz
000292544 7001_ $$0P:(DE-He78)ceccc9aed8c6e89c00795bce1f1d83a3$$aTschaharganeh, Darjus$$b12$$udkfz
000292544 7001_ $$0P:(DE-He78)939d5891259c638c1ab053b1456a578c$$aKrijgsveld, Jeroen$$b13$$eLast author$$udkfz
000292544 7001_ $$0P:(DE-He78)4af0380446b05b5f1995502016151a1b$$aLoayza-Puch, Fabricio$$b14$$eLast author$$udkfz
000292544 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-024-51901-w$$gVol. 15, no. 1, p. 7458$$n1$$p7458$$tNature Communications$$v15$$x2041-1723$$y2024
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