000292567 001__ 292567 000292567 005__ 20240930181835.0 000292567 0247_ $$2doi$$a10.1038/s44276-024-00077-3 000292567 0247_ $$2pmid$$apmid:39233917 000292567 0247_ $$2pmc$$apmc:PMC11368808 000292567 037__ $$aDKFZ-2024-01808 000292567 041__ $$aEnglish 000292567 082__ $$a610 000292567 1001_ $$00000-0001-9347-7913$$aWesselink, Evertine$$b0 000292567 245__ $$aCalcium intake and genetic variants in the calcium sensing receptor in relation to colorectal cancer mortality: an international consortium study of 18,952 patients. 000292567 260__ $$a[London]$$b[Nature Publishing Group UK]$$c2024 000292567 3367_ $$2DRIVER$$aarticle 000292567 3367_ $$2DataCite$$aOutput Types/Journal article 000292567 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1727695216_17246 000292567 3367_ $$2BibTeX$$aARTICLE 000292567 3367_ $$2ORCID$$aJOURNAL_ARTICLE 000292567 3367_ $$00$$2EndNote$$aJournal Article 000292567 500__ $$a BJC Reports (BJC Rep) = 2731-9377 (import from CrossRef, PubMed, , Journals: inrepo02.dkfz.de) 000292567 520__ $$aResearch on calcium intake as well as variants in the calcium sensor receptor (CaSR) gene and their interaction in relation to CRC survival is still limited.Data from 18,952 CRC patients, were included. Associations between primarily pre-diagnostic dietary (n = 13.085), supplemental (n = 11,837), total calcium intake (n = 5970) as well as 325 single nucleotide polymorphisms (SNPs) of the CaSR gene (n = 15,734) in relation to CRC-specific and all-cause mortality were assessed using Cox proportional hazard models. Also interactions between calcium intake and variants in the CaSR gene were assessed.During a median follow-up of 4.8 years (IQR 2.4-8.4), 6801 deaths occurred, of which 4194 related to CRC. For all-cause mortality, no associations were observed for the highest compared to the lowest sex- and study-specific quartile of dietary (HR 1.00, 95%CI 0.92-1.09), supplemental (HR 0.97, 95%CI 0.89-1.06) and total calcium intake (HR 0.99, 95%CI 0.88-1.11). No associations with CRC-specific mortality were observed either. Interactions were observed between supplemental calcium intake and several SNPs of the CaSR gene.Calcium intake was not associated with all-cause or CRC-specific mortality in CRC patients. The association between supplemental calcium intake and all-cause and CRC-specific mortality may be modified by genetic variants in the CaSR gene. 000292567 536__ $$0G:(DE-HGF)POF4-313$$a313 - Krebsrisikofaktoren und Prävention (POF4-313)$$cPOF4-313$$fPOF IV$$x0 000292567 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de 000292567 7001_ $$aGauderman, William$$b1 000292567 7001_ $$aBerndt, Sonja I$$b2 000292567 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b3$$udkfz 000292567 7001_ $$aBuchanan, Daniel D$$b4 000292567 7001_ $$aCampbell, Peter T$$b5 000292567 7001_ $$aChan, Andrew T$$b6 000292567 7001_ $$0P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aChang-Claude, Jenny$$b7$$udkfz 000292567 7001_ $$aCotterchoi, Michelle$$b8 000292567 7001_ $$aGunter, Marc J$$b9 000292567 7001_ $$0P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f$$aHoffmeister, Michael$$b10$$udkfz 000292567 7001_ $$aJoshi, Amit D$$b11 000292567 7001_ $$aNewton, Christina C$$b12 000292567 7001_ $$aPai, Rish K$$b13 000292567 7001_ $$aPellatt, Andrew J$$b14 000292567 7001_ $$aPhipps, Amanda I$$b15 000292567 7001_ $$aSong, Mingyang$$b16 000292567 7001_ $$aUm, Caroline Y$$b17 000292567 7001_ $$avan Guelpen, Bethany$$b18 000292567 7001_ $$aWhite, Emily$$b19 000292567 7001_ $$aPeters, Ulrike$$b20 000292567 7001_ $$avan Duijnhoven, Fränzel J B$$b21 000292567 773__ $$0PERI:(DE-600)3163019-4$$a10.1038/s44276-024-00077-3$$gVol. 2, no. 1, p. 63$$n1$$p63$$tBritish journal of cancer / Reports$$v2$$x2731-9377$$y2024 000292567 909CO $$ooai:inrepo02.dkfz.de:292567$$pVDB 000292567 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aDeutsches Krebsforschungszentrum$$b3$$kDKFZ 000292567 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aDeutsches Krebsforschungszentrum$$b7$$kDKFZ 000292567 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f$$aDeutsches Krebsforschungszentrum$$b10$$kDKFZ 000292567 9131_ $$0G:(DE-HGF)POF4-313$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vKrebsrisikofaktoren und Prävention$$x0 000292567 9141_ $$y2024 000292567 9201_ $$0I:(DE-He78)C070-20160331$$kC070$$lC070 Klinische Epidemiologie und Alternf.$$x0 000292567 9201_ $$0I:(DE-He78)C120-20160331$$kC120$$lPräventive Onkologie$$x1 000292567 9201_ $$0I:(DE-He78)HD01-20160331$$kHD01$$lDKTK HD zentral$$x2 000292567 9201_ $$0I:(DE-He78)C020-20160331$$kC020$$lC020 Epidemiologie von Krebs$$x3 000292567 980__ $$ajournal 000292567 980__ $$aVDB 000292567 980__ $$aI:(DE-He78)C070-20160331 000292567 980__ $$aI:(DE-He78)C120-20160331 000292567 980__ $$aI:(DE-He78)HD01-20160331 000292567 980__ $$aI:(DE-He78)C020-20160331 000292567 980__ $$aUNRESTRICTED