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000292567 005__ 20240930181835.0
000292567 0247_ $$2doi$$a10.1038/s44276-024-00077-3
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000292567 041__ $$aEnglish
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000292567 1001_ $$00000-0001-9347-7913$$aWesselink, Evertine$$b0
000292567 245__ $$aCalcium intake and genetic variants in the calcium sensing receptor in relation to colorectal cancer mortality: an international consortium study of 18,952 patients.
000292567 260__ $$a[London]$$b[Nature Publishing Group UK]$$c2024
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000292567 520__ $$aResearch on calcium intake as well as variants in the calcium sensor receptor (CaSR) gene and their interaction in relation to CRC survival is still limited.Data from 18,952 CRC patients, were included. Associations between primarily pre-diagnostic dietary (n = 13.085), supplemental (n = 11,837), total calcium intake (n = 5970) as well as 325 single nucleotide polymorphisms (SNPs) of the CaSR gene (n = 15,734) in relation to CRC-specific and all-cause mortality were assessed using Cox proportional hazard models. Also interactions between calcium intake and variants in the CaSR gene were assessed.During a median follow-up of 4.8 years (IQR 2.4-8.4), 6801 deaths occurred, of which 4194 related to CRC. For all-cause mortality, no associations were observed for the highest compared to the lowest sex- and study-specific quartile of dietary (HR 1.00, 95%CI 0.92-1.09), supplemental (HR 0.97, 95%CI 0.89-1.06) and total calcium intake (HR 0.99, 95%CI 0.88-1.11). No associations with CRC-specific mortality were observed either. Interactions were observed between supplemental calcium intake and several SNPs of the CaSR gene.Calcium intake was not associated with all-cause or CRC-specific mortality in CRC patients. The association between supplemental calcium intake and all-cause and CRC-specific mortality may be modified by genetic variants in the CaSR gene.
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000292567 7001_ $$aGauderman, William$$b1
000292567 7001_ $$aBerndt, Sonja I$$b2
000292567 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b3$$udkfz
000292567 7001_ $$aBuchanan, Daniel D$$b4
000292567 7001_ $$aCampbell, Peter T$$b5
000292567 7001_ $$aChan, Andrew T$$b6
000292567 7001_ $$0P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aChang-Claude, Jenny$$b7$$udkfz
000292567 7001_ $$aCotterchoi, Michelle$$b8
000292567 7001_ $$aGunter, Marc J$$b9
000292567 7001_ $$0P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f$$aHoffmeister, Michael$$b10$$udkfz
000292567 7001_ $$aJoshi, Amit D$$b11
000292567 7001_ $$aNewton, Christina C$$b12
000292567 7001_ $$aPai, Rish K$$b13
000292567 7001_ $$aPellatt, Andrew J$$b14
000292567 7001_ $$aPhipps, Amanda I$$b15
000292567 7001_ $$aSong, Mingyang$$b16
000292567 7001_ $$aUm, Caroline Y$$b17
000292567 7001_ $$avan Guelpen, Bethany$$b18
000292567 7001_ $$aWhite, Emily$$b19
000292567 7001_ $$aPeters, Ulrike$$b20
000292567 7001_ $$avan Duijnhoven, Fränzel J B$$b21
000292567 773__ $$0PERI:(DE-600)3163019-4$$a10.1038/s44276-024-00077-3$$gVol. 2, no. 1, p. 63$$n1$$p63$$tBritish journal of cancer / Reports$$v2$$x2731-9377$$y2024
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000292567 9201_ $$0I:(DE-He78)C070-20160331$$kC070$$lC070 Klinische Epidemiologie und Alternf.$$x0
000292567 9201_ $$0I:(DE-He78)C120-20160331$$kC120$$lPräventive Onkologie$$x1
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