TY  - JOUR
AU  - Wesselink, Evertine
AU  - Gauderman, William
AU  - Berndt, Sonja I
AU  - Brenner, Hermann
AU  - Buchanan, Daniel D
AU  - Campbell, Peter T
AU  - Chan, Andrew T
AU  - Chang-Claude, Jenny
AU  - Cotterchoi, Michelle
AU  - Gunter, Marc J
AU  - Hoffmeister, Michael
AU  - Joshi, Amit D
AU  - Newton, Christina C
AU  - Pai, Rish K
AU  - Pellatt, Andrew J
AU  - Phipps, Amanda I
AU  - Song, Mingyang
AU  - Um, Caroline Y
AU  - van Guelpen, Bethany
AU  - White, Emily
AU  - Peters, Ulrike
AU  - van Duijnhoven, Fränzel J B
TI  - Calcium intake and genetic variants in the calcium sensing receptor in relation to colorectal cancer mortality: an international consortium study of 18,952 patients.
JO  - British journal of cancer / Reports
VL  - 2
IS  - 1
SN  - 2731-9377
CY  - [London]
PB  - [Nature Publishing Group UK]
M1  - DKFZ-2024-01808
SP  - 63
PY  - 2024
N1  -  BJC Reports (BJC Rep) = 2731-9377 (import from CrossRef, PubMed, , Journals: inrepo02.dkfz.de)
AB  - Research on calcium intake as well as variants in the calcium sensor receptor (CaSR) gene and their interaction in relation to CRC survival is still limited.Data from 18,952 CRC patients, were included. Associations between primarily pre-diagnostic dietary (n = 13.085), supplemental (n = 11,837), total calcium intake (n = 5970) as well as 325 single nucleotide polymorphisms (SNPs) of the CaSR gene (n = 15,734) in relation to CRC-specific and all-cause mortality were assessed using Cox proportional hazard models. Also interactions between calcium intake and variants in the CaSR gene were assessed.During a median follow-up of 4.8 years (IQR 2.4-8.4), 6801 deaths occurred, of which 4194 related to CRC. For all-cause mortality, no associations were observed for the highest compared to the lowest sex- and study-specific quartile of dietary (HR 1.00, 95
LB  - PUB:(DE-HGF)16
C6  - pmid:39233917
C2  - pmc:PMC11368808
DO  - DOI:10.1038/s44276-024-00077-3
UR  - https://inrepo02.dkfz.de/record/292567
ER  -