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@ARTICLE{Wesselink:292567,
      author       = {E. Wesselink and W. Gauderman and S. I. Berndt and H.
                      Brenner$^*$ and D. D. Buchanan and P. T. Campbell and A. T.
                      Chan and J. Chang-Claude$^*$ and M. Cotterchoi and M. J.
                      Gunter and M. Hoffmeister$^*$ and A. D. Joshi and C. C.
                      Newton and R. K. Pai and A. J. Pellatt and A. I. Phipps and
                      M. Song and C. Y. Um and B. van Guelpen and E. White and U.
                      Peters and F. J. B. van Duijnhoven},
      title        = {{C}alcium intake and genetic variants in the calcium
                      sensing receptor in relation to colorectal cancer mortality:
                      an international consortium study of 18,952 patients.},
      journal      = {British journal of cancer / Reports},
      volume       = {2},
      number       = {1},
      issn         = {2731-9377},
      address      = {[London]},
      publisher    = {[Nature Publishing Group UK]},
      reportid     = {DKFZ-2024-01808},
      pages        = {63},
      year         = {2024},
      note         = {BJC Reports (BJC Rep) = 2731-9377 (import from CrossRef,
                      PubMed, , Journals: inrepo02.dkfz.de)},
      abstract     = {Research on calcium intake as well as variants in the
                      calcium sensor receptor (CaSR) gene and their interaction in
                      relation to CRC survival is still limited.Data from 18,952
                      CRC patients, were included. Associations between primarily
                      pre-diagnostic dietary (n = 13.085), supplemental (n =
                      11,837), total calcium intake (n = 5970) as well as 325
                      single nucleotide polymorphisms (SNPs) of the CaSR gene (n =
                      15,734) in relation to CRC-specific and all-cause mortality
                      were assessed using Cox proportional hazard models. Also
                      interactions between calcium intake and variants in the CaSR
                      gene were assessed.During a median follow-up of 4.8 years
                      (IQR 2.4-8.4), 6801 deaths occurred, of which 4194 related
                      to CRC. For all-cause mortality, no associations were
                      observed for the highest compared to the lowest sex- and
                      study-specific quartile of dietary (HR 1.00, $95\%CI$
                      0.92-1.09), supplemental (HR 0.97, $95\%CI$ 0.89-1.06) and
                      total calcium intake (HR 0.99, $95\%CI$ 0.88-1.11). No
                      associations with CRC-specific mortality were observed
                      either. Interactions were observed between supplemental
                      calcium intake and several SNPs of the CaSR gene.Calcium
                      intake was not associated with all-cause or CRC-specific
                      mortality in CRC patients. The association between
                      supplemental calcium intake and all-cause and CRC-specific
                      mortality may be modified by genetic variants in the CaSR
                      gene.},
      cin          = {C070 / C120 / HD01 / C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39233917},
      pmc          = {pmc:PMC11368808},
      doi          = {10.1038/s44276-024-00077-3},
      url          = {https://inrepo02.dkfz.de/record/292567},
}