TY  - JOUR
AU  - Tietze, A.
AU  - Bison, B.
AU  - Engelhardt, J.
AU  - Fenouil, T.
AU  - Figarella-Branger, D.
AU  - Goebell, E.
AU  - Hakumäki, J.
AU  - Koscielniak, E.
AU  - Ludlow, L. E.
AU  - Meyronet, D.
AU  - Nyman, P.
AU  - Øra, I.
AU  - Pesola, J.
AU  - Rauramaa, T.
AU  - Reddingius, R. E.
AU  - Samuel, D.
AU  - Sexton-Oates, A.
AU  - Vasiljevic, A.
AU  - Wefers, A. K.
AU  - Zamecnik, J.
AU  - Jones, Dtw
AU  - Keck, M. K.
AU  - von Hoff, K.
TI  - CNS Embryonal Tumor with PLAGL Amplification, a New Tumor Type in Children and Adolescents: Insights from a Comprehensive MRI Analysis.
JO  - American journal of neuroradiology
VL  - 46
IS  - 3
SN  - 0195-6108
CY  - Oak Brook, Ill.
PB  - Soc.
M1  - DKFZ-2024-01869
SP  - 536-543
PY  - 2025
N1  - 2025 Mar 4;46(3):536-543
AB  - CNS embryonal tumor with PLAGL1/PLAGL2 amplification (ET, PLAGL) is a newly identified, highly malignant pediatric tumor. Systematic MRI descriptions of ET, PLAGL are currently lacking.MRI data from 19 treatment-naïve patients with confirmed ET, PLAGL were analyzed. Evaluation focused on anatomical involvement, tumor localization, MRI signal characteristics, DWI behavior, and the presence of necrosis and hemorrhage. Descriptive statistics (median, interquartile range, percentage) were assessed.Ten patients had PLAGL1 and nine PLAGL2 amplifications. The solid components of the tumors were often multinodular with heterogeneous enhancement (mild to intermediate in 47
LB  - PUB:(DE-HGF)16
C6  - pmid:39271290
DO  - DOI:10.3174/ajnr.A8496
UR  - https://inrepo02.dkfz.de/record/293311
ER  -