TY  - JOUR
AU  - Wang, Sabrina E
AU  - Viallon, Vivian
AU  - Lee, Matthew
AU  - Dimou, Niki
AU  - Hamilton, Fergus
AU  - Biessy, Carine
AU  - O'Mara, Tracy
AU  - Kyrgiou, Maria
AU  - Crosbie, Emma J
AU  - Truong, Therese
AU  - Severi, Gianluca
AU  - Kaaks, Rudolf
AU  - Fortner, Renée Turzanski
AU  - Schulze, Matthias B
AU  - Bendinelli, Benedetta
AU  - Sabina, Sieri
AU  - Tumino, Rosario
AU  - Sacerdote, Carlotta
AU  - Panico, Salvatore
AU  - Crous-Bou, Marta
AU  - Sánchez, Maria-Jose
AU  - Aizpurua, Amaia
AU  - Palacios, Daniel Rodriguez
AU  - Guevara, Marcela
AU  - Travis, Ruth C
AU  - Tsilidis, Konstantinos K
AU  - Heath, Alicia
AU  - Yarmolinsky, James
AU  - Rinaldi, Sabina
AU  - Gunter, Marc J
AU  - Dossus, Laure
TI  - Circulating inflammatory and immune response proteins and endometrial cancer risk: a nested case-control study and Mendelian randomization analyses.
JO  - EBioMedicine
VL  - 108
SN  - 2352-3964
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DKFZ-2024-01871
SP  - 105341
PY  - 2024
AB  - Inflammation and immune dysregulation are hypothesized contributors to endometrial carcinogenesis; however, the precise underlying mechanisms remain unclear.We measured pre-diagnostically 152 plasma protein biomarkers in 624 endometrial cancer case-control pairs nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Odds ratios (ORs) were estimated using conditional logistic regression, accounting for confounding and multiple comparisons. Proteins considered as associated with endometrial cancer risk were further tested in a two-sample Mendelian randomization (MR) analysis using summary data from the UK Biobank (n = 52,363) and the Endometrial Cancer Association Consortium (12,270 cases and 46,126 controls).In the EPIC nested case-control study, IL-6 [OR per NPX (doubling of concentration) = 1.28 (95
KW  - Endometrial cancer (Other)
KW  - HSD11B1 (Other)
KW  - Interleukin-6 (Other)
KW  - Mendelian randomisation (Other)
KW  - Proteomics (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39278107
DO  - DOI:DOI:10.1016/j.ebiom.2024.105341
UR  - https://inrepo02.dkfz.de/record/293318
ER  -