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000293599 1001_ $$aThomas, Claire E$$b0
000293599 245__ $$aCharacterization of additive gene-environment interactions for colorectal cancer risk.
000293599 260__ $$aBaltimore, Md.$$bWolters Kluwer Health, Lippincott Williams & Wilkins$$c2025
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000293599 500__ $$a2025 Jan 1;36(1):126-138
000293599 520__ $$aColorectal cancer (CRC) is a common, fatal cancer. Identifying subgroups who may benefit more from intervention is of critical public health importance. Previous studies have assessed multiplicative interaction between genetic risk scores and environmental factors, but few have assessed additive interaction, the relevant public health measure.Using resources from colorectal cancer consortia including 45,247 CRC cases and 52,671 controls, we assessed multiplicative and additive interaction (relative excess risk due to interaction, RERI) using logistic regression between 13 harmonized environmental factors and genetic risk score including 141 variants associated with CRC risk.There was no evidence of multiplicative interaction between environmental factors and genetic risk score. There was additive interaction where, for individuals with high genetic susceptibility, either heavy drinking [RERI = 0.24, 95% confidence interval, CI, (0.13, 0.36)], ever smoking [0.11 (0.05, 0.16)], high BMI [female 0.09 (0.05, 0.13), male 0.10 (0.05, 0.14)], or high red meat intake [highest versus lowest quartile 0.18 (0.09, 0.27)] was associated with excess CRC risk greater than that for individuals with average genetic susceptibility. Conversely, we estimate those with high genetic susceptibility may benefit more from reducing CRC risk with aspirin/NSAID use [-0.16 (-0.20, -0.11)] or higher intake of fruit, fiber, or calcium [highest quartile versus lowest quartile -0.12 (-0.18, -0.050); -0.16 (-0.23, -0.09); -0.11 (-0.18, -0.05), respectively] than those with average genetic susceptibility.Additive interaction is important to assess for identifying subgroups who may benefit from intervention. The subgroups identified in this study may help inform precision CRC prevention.
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000293599 7001_ $$aLin, Yi$$b1
000293599 7001_ $$aKim, Michelle$$b2
000293599 7001_ $$aKawaguchi, Eric S$$b3
000293599 7001_ $$aQu, Conghui$$b4
000293599 7001_ $$aUm, Caroline Y$$b5
000293599 7001_ $$aLynch, Brigid M$$b6
000293599 7001_ $$aVan Guelpen, Bethany$$b7
000293599 7001_ $$aTsilidis, Kostas$$b8
000293599 7001_ $$aCarreras-Torres, Robert$$b9
000293599 7001_ $$avan Duijnhoven, Franzel Jb$$b10
000293599 7001_ $$aSakoda, Lori C$$b11
000293599 7001_ $$aCampbell, Peter T$$b12
000293599 7001_ $$aTian, Yu$$b13
000293599 7001_ $$0P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aChang-Claude, Jenny$$b14$$udkfz
000293599 7001_ $$aBézieau, Stéphane$$b15
000293599 7001_ $$aBudiarto, Arif$$b16
000293599 7001_ $$aPalmer, Julie R$$b17
000293599 7001_ $$aNewcomb, Polly A$$b18
000293599 7001_ $$aCasey, Graham$$b19
000293599 7001_ $$aLe Marchand, Loic$$b20
000293599 7001_ $$aGiannakis, Marios$$b21
000293599 7001_ $$aLi, Christopher I$$b22
000293599 7001_ $$aGsur, Andrea$$b23
000293599 7001_ $$aNewton, Christina$$b24
000293599 7001_ $$aObón-Santacana, Mireia$$b25
000293599 7001_ $$aMoreno, Victor$$b26
000293599 7001_ $$aVodicka, Pavel$$b27
000293599 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b28$$udkfz
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000293599 7001_ $$aPellatt, Andrew J$$b30
000293599 7001_ $$aSchoen, Robert E$$b31
000293599 7001_ $$aDimou, Niki$$b32
000293599 7001_ $$aMurphy, Neil$$b33
000293599 7001_ $$aGunter, Marc J$$b34
000293599 7001_ $$aCastellví-Bel, Sergi$$b35
000293599 7001_ $$aFigueiredo, Jane C$$b36
000293599 7001_ $$aChan, Andrew T$$b37
000293599 7001_ $$aSong, Mingyang$$b38
000293599 7001_ $$aLi, Li$$b39
000293599 7001_ $$aBishop, D Timothy$$b40
000293599 7001_ $$aGruber, Stephen B$$b41
000293599 7001_ $$aBaurley, James W$$b42
000293599 7001_ $$aBien, Stephanie A$$b43
000293599 7001_ $$aConti, David V$$b44
000293599 7001_ $$aHuyghe, Jeroen R$$b45
000293599 7001_ $$aKundaje, Anshul$$b46
000293599 7001_ $$aSu, Yu-Ru$$b47
000293599 7001_ $$aWang, Jun$$b48
000293599 7001_ $$aKeku, Temitope O$$b49
000293599 7001_ $$aWoods, Michael O$$b50
000293599 7001_ $$aBerndt, Sonja I$$b51
000293599 7001_ $$aChanock, Stephen J$$b52
000293599 7001_ $$aTangen, Catherine M$$b53
000293599 7001_ $$aWolk, Alicja$$b54
000293599 7001_ $$aBurnett-Hartman, Andrea$$b55
000293599 7001_ $$aWu, Anna H$$b56
000293599 7001_ $$aWhite, Emily$$b57
000293599 7001_ $$aDevall, Matthew A$$b58
000293599 7001_ $$aDíez-Obrero, Virginia$$b59
000293599 7001_ $$aDrew, David A$$b60
000293599 7001_ $$aGiovannucci, Edward$$b61
000293599 7001_ $$aHidaka, Akihisa$$b62
000293599 7001_ $$aKim, Andre E$$b63
000293599 7001_ $$aLewinger, Juan Pablo$$b64
000293599 7001_ $$aMorrison, John$$b65
000293599 7001_ $$aOse, Jennifer$$b66
000293599 7001_ $$aPapadimitriou, Nikos$$b67
000293599 7001_ $$aPardamean, Bens$$b68
000293599 7001_ $$aPeoples, Anita R$$b69
000293599 7001_ $$aRuiz-Narvaez, Edward A$$b70
000293599 7001_ $$aShcherbina, Anna$$b71
000293599 7001_ $$aStern, Mariana C$$b72
000293599 7001_ $$aChen, Xuechen$$b73
000293599 7001_ $$aThomas, Duncan C$$b74
000293599 7001_ $$aPlatz, Elizabeth A$$b75
000293599 7001_ $$aGauderman, W James$$b76
000293599 7001_ $$aPeters, Ulrike$$b77
000293599 7001_ $$aHsu, Li$$b78
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