TY  - JOUR
AU  - Thomas, Claire E
AU  - Lin, Yi
AU  - Kim, Michelle
AU  - Kawaguchi, Eric S
AU  - Qu, Conghui
AU  - Um, Caroline Y
AU  - Lynch, Brigid M
AU  - Van Guelpen, Bethany
AU  - Tsilidis, Kostas
AU  - Carreras-Torres, Robert
AU  - van Duijnhoven, Franzel Jb
AU  - Sakoda, Lori C
AU  - Campbell, Peter T
AU  - Tian, Yu
AU  - Chang-Claude, Jenny
AU  - Bézieau, Stéphane
AU  - Budiarto, Arif
AU  - Palmer, Julie R
AU  - Newcomb, Polly A
AU  - Casey, Graham
AU  - Le Marchand, Loic
AU  - Giannakis, Marios
AU  - Li, Christopher I
AU  - Gsur, Andrea
AU  - Newton, Christina
AU  - Obón-Santacana, Mireia
AU  - Moreno, Victor
AU  - Vodicka, Pavel
AU  - Brenner, Hermann
AU  - Hoffmeister, Michael
AU  - Pellatt, Andrew J
AU  - Schoen, Robert E
AU  - Dimou, Niki
AU  - Murphy, Neil
AU  - Gunter, Marc J
AU  - Castellví-Bel, Sergi
AU  - Figueiredo, Jane C
AU  - Chan, Andrew T
AU  - Song, Mingyang
AU  - Li, Li
AU  - Bishop, D Timothy
AU  - Gruber, Stephen B
AU  - Baurley, James W
AU  - Bien, Stephanie A
AU  - Conti, David V
AU  - Huyghe, Jeroen R
AU  - Kundaje, Anshul
AU  - Su, Yu-Ru
AU  - Wang, Jun
AU  - Keku, Temitope O
AU  - Woods, Michael O
AU  - Berndt, Sonja I
AU  - Chanock, Stephen J
AU  - Tangen, Catherine M
AU  - Wolk, Alicja
AU  - Burnett-Hartman, Andrea
AU  - Wu, Anna H
AU  - White, Emily
AU  - Devall, Matthew A
AU  - Díez-Obrero, Virginia
AU  - Drew, David A
AU  - Giovannucci, Edward
AU  - Hidaka, Akihisa
AU  - Kim, Andre E
AU  - Lewinger, Juan Pablo
AU  - Morrison, John
AU  - Ose, Jennifer
AU  - Papadimitriou, Nikos
AU  - Pardamean, Bens
AU  - Peoples, Anita R
AU  - Ruiz-Narvaez, Edward A
AU  - Shcherbina, Anna
AU  - Stern, Mariana C
AU  - Chen, Xuechen
AU  - Thomas, Duncan C
AU  - Platz, Elizabeth A
AU  - Gauderman, W James
AU  - Peters, Ulrike
AU  - Hsu, Li
TI  - Characterization of additive gene-environment interactions for colorectal cancer risk.
JO  - Epidemiology
VL  - 36
IS  - 1
SN  - 1044-3983
CY  - Baltimore, Md.
PB  - Wolters Kluwer Health, Lippincott Williams & Wilkins
M1  - DKFZ-2024-01916
SP  - 126-138
PY  - 2025
N1  - 2025 Jan 1;36(1):126-138
AB  - Colorectal cancer (CRC) is a common, fatal cancer. Identifying subgroups who may benefit more from intervention is of critical public health importance. Previous studies have assessed multiplicative interaction between genetic risk scores and environmental factors, but few have assessed additive interaction, the relevant public health measure.Using resources from colorectal cancer consortia including 45,247 CRC cases and 52,671 controls, we assessed multiplicative and additive interaction (relative excess risk due to interaction, RERI) using logistic regression between 13 harmonized environmental factors and genetic risk score including 141 variants associated with CRC risk.There was no evidence of multiplicative interaction between environmental factors and genetic risk score. There was additive interaction where, for individuals with high genetic susceptibility, either heavy drinking [RERI = 0.24, 95
LB  - PUB:(DE-HGF)16
C6  - pmid:39316822
DO  - DOI:10.1097/EDE.0000000000001795
UR  - https://inrepo02.dkfz.de/record/293599
ER  -