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@ARTICLE{Thomas:293599,
      author       = {C. E. Thomas and Y. Lin and M. Kim and E. S. Kawaguchi and
                      C. Qu and C. Y. Um and B. M. Lynch and B. Van Guelpen and K.
                      Tsilidis and R. Carreras-Torres and F. J. van Duijnhoven and
                      L. C. Sakoda and P. T. Campbell and Y. Tian and J.
                      Chang-Claude$^*$ and S. Bézieau and A. Budiarto and J. R.
                      Palmer and P. A. Newcomb and G. Casey and L. Le Marchand and
                      M. Giannakis and C. I. Li and A. Gsur and C. Newton and M.
                      Obón-Santacana and V. Moreno and P. Vodicka and H.
                      Brenner$^*$ and M. Hoffmeister$^*$ and A. J. Pellatt and R.
                      E. Schoen and N. Dimou and N. Murphy and M. J. Gunter and S.
                      Castellví-Bel and J. C. Figueiredo and A. T. Chan and M.
                      Song and L. Li and D. T. Bishop and S. B. Gruber and J. W.
                      Baurley and S. A. Bien and D. V. Conti and J. R. Huyghe and
                      A. Kundaje and Y.-R. Su and J. Wang and T. O. Keku and M. O.
                      Woods and S. I. Berndt and S. J. Chanock and C. M. Tangen
                      and A. Wolk and A. Burnett-Hartman and A. H. Wu and E. White
                      and M. A. Devall and V. Díez-Obrero and D. A. Drew and E.
                      Giovannucci and A. Hidaka and A. E. Kim and J. P. Lewinger
                      and J. Morrison and J. Ose and N. Papadimitriou and B.
                      Pardamean and A. R. Peoples and E. A. Ruiz-Narvaez and A.
                      Shcherbina and M. C. Stern and X. Chen and D. C. Thomas and
                      E. A. Platz and W. J. Gauderman and U. Peters and L. Hsu},
      title        = {{C}haracterization of additive gene-environment
                      interactions for colorectal cancer risk.},
      journal      = {Epidemiology},
      volume       = {36},
      number       = {1},
      issn         = {1044-3983},
      address      = {Baltimore, Md.},
      publisher    = {Wolters Kluwer Health, Lippincott Williams $\&$ Wilkins},
      reportid     = {DKFZ-2024-01916},
      pages        = {126-138},
      year         = {2025},
      note         = {2025 Jan 1;36(1):126-138},
      abstract     = {Colorectal cancer (CRC) is a common, fatal cancer.
                      Identifying subgroups who may benefit more from intervention
                      is of critical public health importance. Previous studies
                      have assessed multiplicative interaction between genetic
                      risk scores and environmental factors, but few have assessed
                      additive interaction, the relevant public health
                      measure.Using resources from colorectal cancer consortia
                      including 45,247 CRC cases and 52,671 controls, we assessed
                      multiplicative and additive interaction (relative excess
                      risk due to interaction, RERI) using logistic regression
                      between 13 harmonized environmental factors and genetic risk
                      score including 141 variants associated with CRC risk.There
                      was no evidence of multiplicative interaction between
                      environmental factors and genetic risk score. There was
                      additive interaction where, for individuals with high
                      genetic susceptibility, either heavy drinking [RERI = 0.24,
                      $95\%$ confidence interval, CI, (0.13, 0.36)], ever smoking
                      [0.11 (0.05, 0.16)], high BMI [female 0.09 (0.05, 0.13),
                      male 0.10 (0.05, 0.14)], or high red meat intake [highest
                      versus lowest quartile 0.18 (0.09, 0.27)] was associated
                      with excess CRC risk greater than that for individuals with
                      average genetic susceptibility. Conversely, we estimate
                      those with high genetic susceptibility may benefit more from
                      reducing CRC risk with aspirin/NSAID use [-0.16 (-0.20,
                      -0.11)] or higher intake of fruit, fiber, or calcium
                      [highest quartile versus lowest quartile -0.12 (-0.18,
                      -0.050); -0.16 (-0.23, -0.09); -0.11 (-0.18, -0.05),
                      respectively] than those with average genetic
                      susceptibility.Additive interaction is important to assess
                      for identifying subgroups who may benefit from intervention.
                      The subgroups identified in this study may help inform
                      precision CRC prevention.},
      cin          = {C020 / C070 / C120 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)C120-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39316822},
      doi          = {10.1097/EDE.0000000000001795},
      url          = {https://inrepo02.dkfz.de/record/293599},
}