000293614 001__ 293614
000293614 005__ 20250731105425.0
000293614 0247_ $$2doi$$a10.1002/ijc.35196
000293614 0247_ $$2pmid$$apmid:39319538
000293614 0247_ $$2ISSN$$a0020-7136
000293614 0247_ $$2ISSN$$a1097-0215
000293614 0247_ $$2altmetric$$aaltmetric:168826008
000293614 037__ $$aDKFZ-2024-01930
000293614 041__ $$aEnglish
000293614 082__ $$a610
000293614 1001_ $$aGálvez-Montosa, Fernando$$b0
000293614 245__ $$aPolymorphisms within autophagy-related genes as susceptibility biomarkers for pancreatic cancer: A meta-analysis of three large European cohorts and functional characterization.
000293614 260__ $$aBognor Regis$$bWiley-Liss$$c2025
000293614 3367_ $$2DRIVER$$aarticle
000293614 3367_ $$2DataCite$$aOutput Types/Journal article
000293614 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1732196233_5932
000293614 3367_ $$2BibTeX$$aARTICLE
000293614 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000293614 3367_ $$00$$2EndNote$$aJournal Article
000293614 500__ $$a2025 Jan 15;156(2):339-352
000293614 520__ $$aPancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with patients having unresectable or metastatic disease at diagnosis, with poor prognosis and very short survival. Given that genetic variation within autophagy-related genes influences autophagic flux and susceptibility to solid cancers, we decided to investigate whether 55,583 single nucleotide polymorphisms (SNPs) within 234 autophagy-related genes could influence the risk of developing PDAC in three large independent cohorts of European ancestry including 12,754 PDAC cases and 324,926 controls. The meta-analysis of these populations identified, for the first time, the association of the BIDrs9604789 variant with an increased risk of developing the disease (ORMeta = 1.31, p = 9.67 × 10-6). We also confirmed the association of TP63rs1515496 and TP63rs35389543 variants with PDAC risk (OR = 0.89, p = 6.27 × 10-8 and OR = 1.16, p = 2.74 × 10-5). Although it is known that BID induces autophagy and TP63 promotes cell growth, cell motility and invasion, we also found that carriers of the TP63rs1515496G allele had increased numbers of FOXP3+ Helios+ T regulatory cells and CD45RA+ T regulatory cells (p = 7.67 × 10-4 and p = 1.56 × 10-3), but also decreased levels of CD4+ T regulatory cells (p = 7.86 × 10-4). These results were in agreement with research suggesting that the TP63rs1515496 variant alters binding sites for FOXA1 and CTCF, which are transcription factors involved in modulating specific subsets of regulatory T cells. In conclusion, this study identifies BID as new susceptibility locus for PDAC and confirms previous studies suggesting that the TP63 gene is involved in the development of PDAC. This study also suggests new pathogenic mechanisms of the TP63 locus in PDAC.
000293614 536__ $$0G:(DE-HGF)POF4-313$$a313 - Krebsrisikofaktoren und Prävention (POF4-313)$$cPOF4-313$$fPOF IV$$x0
000293614 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000293614 650_7 $$2Other$$aautophagy
000293614 650_7 $$2Other$$afunctional characterization
000293614 650_7 $$2Other$$agenetic variants
000293614 650_7 $$2Other$$apancreatic cancer
000293614 650_7 $$2Other$$apolymorphisms
000293614 650_7 $$2Other$$asusceptibility
000293614 7001_ $$aPeduzzi, Giulia$$b1
000293614 7001_ $$0P:(DE-HGF)0$$aSanchez-Maldonado, José Manuel$$b2
000293614 7001_ $$aTer Horst, Rob$$b3
000293614 7001_ $$aCabrera-Serrano, Antonio J$$b4
000293614 7001_ $$aGentiluomo, Manuel$$b5
000293614 7001_ $$0P:(DE-He78)b791a47b92809f7c54501331f72e0243$$aMacauda, Angelica$$b6$$udkfz
000293614 7001_ $$aLuque, Natalia$$b7
000293614 7001_ $$0P:(DE-He78)0149ac455a0174a847bd30162edf897b$$aÜnal, Pelin$$b8$$udkfz
000293614 7001_ $$aGarcía-Verdejo, Francisco Javier$$b9
000293614 7001_ $$aLi, Yang$$b10
000293614 7001_ $$aLópez López, José Antonio$$b11
000293614 7001_ $$0P:(DE-He78)c2ba7331c92b97094f5a95778f3d1940$$aStein, Angelika$$b12$$udkfz
000293614 7001_ $$aBueno-de-Mesquita, H Bas$$b13
000293614 7001_ $$aArcidiacono, Paolo Giorgio$$b14
000293614 7001_ $$aZanette, Dalila Luciola$$b15
000293614 7001_ $$aKahlert, Christoph$$b16
000293614 7001_ $$aPerri, Francesco$$b17
000293614 7001_ $$00000-0002-4294-6799$$aSoucek, Pavel$$b18
000293614 7001_ $$aTalar-Wojnarowska, Renata$$b19
000293614 7001_ $$aTheodoropoulos, George E$$b20
000293614 7001_ $$aIzbicki, Jakob R$$b21
000293614 7001_ $$aTamás, Hussein$$b22
000293614 7001_ $$aVan Laarhoven, Hanneke$$b23
000293614 7001_ $$aNappo, Gennaro$$b24
000293614 7001_ $$aPetrone, Maria Chiara$$b25
000293614 7001_ $$aLovecek, Martin$$b26
000293614 7001_ $$aVermeulen, Roel C H$$b27
000293614 7001_ $$aAdamonis, Kestutis$$b28
000293614 7001_ $$aReyes-Zurita, Fernando Jesus$$b29
000293614 7001_ $$0P:(DE-He78)53e1a2846c69064e27790dbf349ccaec$$aHolleczek, Bernd$$b30$$udkfz
000293614 7001_ $$aSumskiene, Jolanta$$b31
000293614 7001_ $$aMohelníková-Duchoňová, Beatrice$$b32
000293614 7001_ $$aLawlor, Rita T$$b33
000293614 7001_ $$aPezzilli, Raffaele$$b34
000293614 7001_ $$aAoki, Mateus Nobrega$$b35
000293614 7001_ $$aPasquali, Claudio$$b36
000293614 7001_ $$aPetrenkiene, Vitalija$$b37
000293614 7001_ $$aBasso, Daniela$$b38
000293614 7001_ $$aBunduc, Stefania$$b39
000293614 7001_ $$aComandatore, Annalisa$$b40
000293614 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b41$$udkfz
000293614 7001_ $$aErmini, Stefano$$b42
000293614 7001_ $$aVanella, Giuseppe$$b43
000293614 7001_ $$aGoetz, Mara R$$b44
000293614 7001_ $$aArchibugi, Livia$$b45
000293614 7001_ $$aLucchesi, Maurizio$$b46
000293614 7001_ $$aUzunoglu, Faik Guntac$$b47
000293614 7001_ $$aBusch, Olivier$$b48
000293614 7001_ $$aMilanetto, Anna Caterina$$b49
000293614 7001_ $$aPuzzono, Marta$$b50
000293614 7001_ $$aKupcinskas, Juozas$$b51
000293614 7001_ $$aMorelli, Luca$$b52
000293614 7001_ $$aSperti, Cosimo$$b53
000293614 7001_ $$aCarrara, Silvia$$b54
000293614 7001_ $$aCapurso, Gabriele$$b55
000293614 7001_ $$avan Eijck, Casper H J$$b56
000293614 7001_ $$aOliverius, Martin$$b57
000293614 7001_ $$aRoth, Susanne$$b58
000293614 7001_ $$00000-0002-8831-7349$$aTavano, Francesca$$b59
000293614 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b60$$udkfz
000293614 7001_ $$aSzentesi, Andrea$$b61
000293614 7001_ $$aVodickova, Ludmila$$b62
000293614 7001_ $$aLuchini, Claudio$$b63
000293614 7001_ $$0P:(DE-He78)c67a12496b8aac150c0eef888d808d46$$aSchöttker, Ben$$b64$$udkfz
000293614 7001_ $$00000-0001-8364-6357$$aLandi, Stefano$$b65
000293614 7001_ $$aDohan, Orsolya$$b66
000293614 7001_ $$aTacelli, Matteo$$b67
000293614 7001_ $$aGreenhalf, William$$b68
000293614 7001_ $$00000-0002-3295-6811$$aGazouli, Maria$$b69
000293614 7001_ $$aNeoptolemos, John P$$b70
000293614 7001_ $$aCavestro, Giulia Martina$$b71
000293614 7001_ $$aBoggi, Ugo$$b72
000293614 7001_ $$aLatiano, Anna$$b73
000293614 7001_ $$aHegyi, Péter$$b74
000293614 7001_ $$aGinocchi, Laura$$b75
000293614 7001_ $$aNetea, Mihai G$$b76
000293614 7001_ $$aSánchez-Rovira, Pedro$$b77
000293614 7001_ $$0P:(DE-He78)5323704270b6393dcea70186ffd86bca$$aCanzian, Federico$$b78$$udkfz
000293614 7001_ $$00000-0003-3220-9944$$aCampa, Daniele$$b79
000293614 7001_ $$00000-0002-9355-2423$$aSainz, Juan$$b80
000293614 773__ $$0PERI:(DE-600)1474822-8$$a10.1002/ijc.35196$$gp. ijc.35196$$n2$$p339-352$$tInternational journal of cancer$$v156$$x0020-7136$$y2025
000293614 8564_ $$uhttps://inrepo02.dkfz.de/record/293614/files/Intl%20Journal%20of%20Cancer%20-%202024%20-%20G%C3%A1lvez%E2%80%90Montosa%20-%20Polymorphisms%20within%20autophagy%E2%80%90related%20genes%20as%20susceptibility%20biomarkers.pdf
000293614 8564_ $$uhttps://inrepo02.dkfz.de/record/293614/files/Intl%20Journal%20of%20Cancer%20-%202024%20-%20G%C3%A1lvez%E2%80%90Montosa%20-%20Polymorphisms%20within%20autophagy%E2%80%90related%20genes%20as%20susceptibility%20biomarkers.pdf?subformat=pdfa$$xpdfa
000293614 909CO $$ooai:inrepo02.dkfz.de:293614$$pVDB
000293614 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b2$$kDKFZ
000293614 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)b791a47b92809f7c54501331f72e0243$$aDeutsches Krebsforschungszentrum$$b6$$kDKFZ
000293614 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)0149ac455a0174a847bd30162edf897b$$aDeutsches Krebsforschungszentrum$$b8$$kDKFZ
000293614 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)c2ba7331c92b97094f5a95778f3d1940$$aDeutsches Krebsforschungszentrum$$b12$$kDKFZ
000293614 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)53e1a2846c69064e27790dbf349ccaec$$aDeutsches Krebsforschungszentrum$$b30$$kDKFZ
000293614 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aDeutsches Krebsforschungszentrum$$b41$$kDKFZ
000293614 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aDeutsches Krebsforschungszentrum$$b60$$kDKFZ
000293614 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)c67a12496b8aac150c0eef888d808d46$$aDeutsches Krebsforschungszentrum$$b64$$kDKFZ
000293614 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)5323704270b6393dcea70186ffd86bca$$aDeutsches Krebsforschungszentrum$$b78$$kDKFZ
000293614 9131_ $$0G:(DE-HGF)POF4-313$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vKrebsrisikofaktoren und Prävention$$x0
000293614 9141_ $$y2024
000293614 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz$$d2023-10-21$$wger
000293614 915__ $$0StatID:(DE-HGF)3001$$2StatID$$aDEAL Wiley$$d2023-10-21$$wger
000293614 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-10-21
000293614 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-10-21
000293614 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-10-21
000293614 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2023-10-21
000293614 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2023-10-21
000293614 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-10-21
000293614 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2023-10-21
000293614 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2023-10-21
000293614 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2023-10-21
000293614 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bINT J CANCER : 2022$$d2023-10-21
000293614 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bINT J CANCER : 2022$$d2023-10-21
000293614 9201_ $$0I:(DE-He78)C055-20160331$$kC055$$lGenomische Epidemiologie$$x0
000293614 9201_ $$0I:(DE-He78)C070-20160331$$kC070$$lC070 Klinische Epidemiologie und Alternf.$$x1
000293614 9201_ $$0I:(DE-He78)HD01-20160331$$kHD01$$lDKTK HD zentral$$x2
000293614 9201_ $$0I:(DE-He78)C020-20160331$$kC020$$lC020 Epidemiologie von Krebs$$x3
000293614 980__ $$ajournal
000293614 980__ $$aVDB
000293614 980__ $$aI:(DE-He78)C055-20160331
000293614 980__ $$aI:(DE-He78)C070-20160331
000293614 980__ $$aI:(DE-He78)HD01-20160331
000293614 980__ $$aI:(DE-He78)C020-20160331
000293614 980__ $$aUNRESTRICTED