TY  - JOUR
AU  - Hemminki, Kari
AU  - Zitricky, Frantisek
AU  - Försti, Asta
AU  - Tapaninen, Tuija
AU  - Hemminki, Akseli
AU  - Juliusson, Gunnar
AU  - Niemann, Carsten Utoft
TI  - Complex Relationships between Diagnostics and Survival in Chronic Lymphocytic Leukemia in Denmark, Finland, Norway, and Sweden.
JO  - Cancers
VL  - 16
IS  - 18
SN  - 2072-6694
CY  - Basel
PB  - MDPI
M1  - DKFZ-2024-01955
SP  - 3229
PY  - 2024
N1  - #EA:Z999#
AB  - Chronic lymphocytic leukemia (CLL) is a common hematological malignancy with highly variable clinical presentation. Many patients never require any treatment but for the others, chemotherapy, immunochemotherapy, and newer targeted therapies have changed the treatment landscape. Diagnostic age influences the applied treatment, and we thus wanted to analyze age-specific survival trends through 50 years up to 2020s.We used 1- and 5-year relative survival from the NORDCAN database, with data from Denmark (DK), Finland (FI), Norway (NO), and Sweden (SE). Because of the variable presentation of CLL, we also considered incidence and mortality trends. For comparison, US SEER data were used.The large age-specific survival differences in 1972-76 almost disappeared by 2017-21. While 5-year survival in younger patients exceeded 90
KW  - periodic survival (Other)
KW  - prognosis (Other)
KW  - targeted agents (Other)
KW  - treatment (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39335200
C2  - pmc:PMC11429559
DO  - DOI:10.3390/cancers16183229
UR  - https://inrepo02.dkfz.de/record/293797
ER  -