TY  - JOUR
AU  - Shi, Fanchao
AU  - Chowdhury, Rajiv
AU  - Sofianopoulou, Eleni
AU  - Koulman, Albert
AU  - Sun, Luanluan
AU  - Steur, Marinka
AU  - Aleksandrova, Krasimira
AU  - Dahm, Christina C
AU  - Schulze, Matthias B
AU  - van der Schouw, Yvonne T
AU  - Agnoli, Claudia
AU  - Amiano, Pilar
AU  - Boer, Jolanda M A
AU  - Bork, Christian S
AU  - Cabrera-Castro, Natalia
AU  - Eichelmann, Fabian
AU  - Elbaz, Alexis
AU  - Farràs, Marta
AU  - Heath, Alicia K
AU  - Kaaks, Rudolf
AU  - Katzke, Verena
AU  - Keski-Rahkonen, Pekka
AU  - Masala, Giovanna
AU  - Moreno-Iribas, Conchi
AU  - Panico, Salvatore
AU  - Papier, Keren
AU  - Petrova, Dafina
AU  - Quirós, J Ramón
AU  - Ricceri, Fulvio
AU  - Severi, Gianluca
AU  - Tjønneland, Anne
AU  - Tong, Tammy Y N
AU  - Tumino, Rosario
AU  - Wareham, Nick
AU  - Weiderpass, Elisabete
AU  - Di Angelantonio, Emanuele
AU  - Forouhi, Nita
AU  - Danesh, John
AU  - Butterworth, Adam S
AU  - Kaptoge, Stephen
TI  - Association of circulating fatty acids with cardiovascular disease risk: Analysis of individual-level data in three large prospective cohorts and updated meta-analysis.
JO  - European journal of preventive cardiology
VL  - 32
IS  - 3
SN  - 2047-4873
CY  - Oxford
PB  - Oxford University Press
M1  - DKFZ-2024-02000
SP  - 233-246
PY  - 2025
N1  - 2025 Feb 18;32(3):233-246
AB  - Associations of saturated and unsaturated fatty acids (FAs) with cardiovascular disease (CVD) remain controversial. We therefore aimed to investigate the prospective associations of objectively measured FAs with CVD, including incident coronary heart disease (CHD) and stroke, as well as CVD mortality.Circulating FA concentrations expressed as the percentage of total FAs were assayed in 172,891 participants without prior vascular disease at baseline from the European Prospective Investigation into Cancer and Nutrition-CVD (EPIC-CVD) (7,343 CHD; 6,499 stroke), UK Biobank (1,825; 1,474), and INTERVAL (285; 209) cohort studies. Hazard ratio (HR) per 1-standard deviation (SD) higher FA concentrations was estimated using Cox regression models and pooled by random-effects meta-analysis. Systematic reviews with meta-analysis published by 6 May 2023 on associations between FAs and CVDs were systematically searched and updated meta-analyses using random-effects model were conducted. Evidence from randomized controlled trials (RCTs) was also summarized.Higher concentrations of total saturated FAs (SFAs) were associated with higher cardiovascular risks in the combined analysis, with differential findings noted for SFA subtypes in further analysis restricted to EPIC-CVD: positive associations for even-chain SFA [HR for CHD 1.24 (95
LB  - PUB:(DE-HGF)16
C6  - pmid:39365172
DO  - DOI:10.1093/eurjpc/zwae315
UR  - https://inrepo02.dkfz.de/record/293933
ER  -