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@ARTICLE{Stein:293954,
      author       = {J. Stein and A. Pabst and K. Berger and A. Karch and H.
                      Teismann and F. Streit and H. J. Grabe and R. Mikolajczyk
                      and J. Massag and W. Lieb and S. Castell and J.-K. Heise and
                      M. B. Schulze and S. Gastell and V. Harth and N. Obi and A.
                      Peters and M.-T. Huemer and P. Bohmann and M. Leitzmann and
                      S. Schipf and C. Meinke-Franze and A. Hebestreit and D. C.
                      Fuhr and K. B. Michels and S. Jaskulski and H. Stocker$^*$
                      and L. Koch-Gallenkamp$^*$ and S. N. Willich and T. Keil and
                      M. Löffler and K. Wirkner and S. G. Riedel-Heller},
      collaboration = {f. G. N. Cohort},
      title        = {{M}ental health of individuals with pre-existing mental
                      illnesses at the beginning of the {COVID}-19 pandemic:
                      results of the {G}erman {N}ational {C}ohort ({NAKO}).},
      journal      = {Frontiers in Public Health},
      volume       = {12},
      issn         = {2296-2565},
      address      = {Lausanne},
      publisher    = {Frontiers Media},
      reportid     = {DKFZ-2024-02019},
      pages        = {1451631},
      year         = {2024},
      abstract     = {The COVID-19 pandemic prompted a range of studies on mental
                      health, with mixed results. While numerous studies reported
                      worsened conditions in individuals with pre-existing mental
                      disorders, others showed resilience and stability in mental
                      health. However, longitudinal data focusing on the German
                      population are sparse, especially regarding effects of age
                      and pre-existing mental disorders during the early stages of
                      the pandemic.To assess the interplay between psychiatric
                      history, age, and the timing of the pandemic, with a focus
                      on understanding how these factors relate to the severity of
                      depression and anxiety symptoms.Exploratory analyses were
                      based on 135,445 individuals aged 20-72 years from the
                      German National Cohort (NAKO). Depressive and anxiety
                      symptoms were assessed before and after the first wave of
                      the pandemic. Inferential statistical analyses and negative
                      binomial regression models were calculated.Persons with a
                      self-reported psychiatric history exhibited comparable
                      levels of depression and anxiety symptom severity after the
                      first wave of the pandemic compared to the time before. In
                      contrast, individuals without a psychiatric history,
                      particularly those in their 20s to 40s, experienced an
                      increase in mental health symptom severity during the first
                      wave of the pandemic.Analyses focuses on the first wave of
                      the pandemic, leaving the long-term mental health effects
                      unexplored.Future research should consider age-specific and
                      mental-health-related factors when addressing global health
                      crises. Additionally, it is important to explore factors
                      influencing resilience and adaptation, aiming to develop
                      targeted interventions and informed policies for effective
                      mental health management during pandemics.},
      keywords     = {Humans / COVID-19: epidemiology / COVID-19: psychology /
                      Middle Aged / Germany: epidemiology / Adult / Male / Female
                      / Aged / Anxiety: epidemiology / Depression: epidemiology /
                      Depression: psychology / Mental Health: statistics $\&$
                      numerical data / Mental Disorders: epidemiology / Mental
                      Disorders: psychology / Cohort Studies / Young Adult /
                      Pandemics / Age Factors / SARS-CoV-2 / Severity of Illness
                      Index / COVID-19 pandemic (Other) / German National Cohort
                      (NAKO) (Other) / anxiety (Other) / depression (Other) /
                      longitudinal cohort study (Other) / mental health (Other)},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39377001},
      pmc          = {pmc:PMC11456423},
      doi          = {10.3389/fpubh.2024.1451631},
      url          = {https://inrepo02.dkfz.de/record/293954},
}