TY  - JOUR
AU  - Grenville, Zoe S
AU  - Noor, Urwah
AU  - Rinaldi, Sabina
AU  - Gunter, Marc J
AU  - Ferrari, Pietro
AU  - Agnoli, Claudia
AU  - Amiano, Pilar
AU  - Catalano, Alberto
AU  - Chirlaque, María Dolores
AU  - Christakoudi, Sofia
AU  - Guevara, Marcela
AU  - Johansson, Matthias
AU  - Kaaks, Rudolf
AU  - Katzke, Verena
AU  - Masala, Giovanna
AU  - Olsen, Anja
AU  - Papier, Keren
AU  - Sánchez, Maria-Jose
AU  - Schulze, Matthias B
AU  - Tjønneland, Anne
AU  - Tong, Tammy Y N
AU  - Tumino, Rosario
AU  - Weiderpass, Elisabete
AU  - Zamora-Ros, Raul
AU  - Key, Timothy J
AU  - Smith-Byrne, Karl
AU  - Schmidt, Julie A
AU  - Travis, Ruth C
TI  - Perturbations in the blood metabolome up to a decade before prostate cancer diagnosis in 4387 matched case-control sets from the European Prospective Investigation into Cancer and Nutrition.
JO  - International journal of cancer
VL  - 156
IS  - 5
SN  - 0020-7136
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2024-02021
SP  - 943-952
PY  - 2025
N1  - 2025 Mar 1;156(5):943-952
AB  - Measuring pre-diagnostic blood metabolites may help identify novel risk factors for prostate cancer. Using data from 4387 matched case-control pairs from the European Prospective Investigation into Cancer and Nutrition (EPIC) study, we investigated the associations of 148 individual metabolites and three previously defined metabolite patterns with prostate cancer risk. Metabolites were measured by liquid chromatography-mass spectrometry. Multivariable-adjusted conditional logistic regression was used to estimate the odds ratio per standard deviation increase in log metabolite concentration and metabolite patterns (OR1SD) for prostate cancer overall, and for advanced, high-grade, aggressive. We corrected for multiple testing using the Benjamini-Hochberg method. Overall, there were no associations between specific metabolites or metabolite patterns and overall, aggressive, or high-grade prostate cancer that passed the multiple testing threshold (padj <0.05). Six phosphatidylcholines (PCs) were inversely associated with advanced prostate cancer diagnosed at or within 10 years of blood collection. metabolite patterns 1 (64 PCs and three hydroxysphingomyelins) and 2 (two acylcarnitines, glutamate, ornithine, and taurine) were also inversely associated with advanced prostate cancer; when stratified by follow-up time, these associations were observed for diagnoses at or within 10 years of recruitment (OR1SD 0.80, 95
KW  - European prospective investigation into cancer and nutrition (EPIC) (Other)
KW  - cancer biomarkers (Other)
KW  - metabolomics (Other)
KW  - prospective cohort (Other)
KW  - prostate cancer (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39378119
DO  - DOI:10.1002/ijc.35208
UR  - https://inrepo02.dkfz.de/record/293956
ER  -