Perturbations in the blood metabolome up to a decade before prostate cancer diagnosis in 4387 matched case-control sets from the European Prospective Investigation into Cancer and Nutrition.

Grenville, Zoe S; Johansson, Matthias; Kaaks, Rudolf; Tumino, Rosario; Tjønneland, Anne; Ferrari, Pietro; Papier, Keren; Noor, Urwah; Christakoudi, Sofia; Schmidt, Julie A; Amiano, Pilar; Tong, Tammy Y N; Zamora-Ros, Raul; Chirlaque, María Dolores; Weiderpass, Elisabete; Rinaldi, Sabina; Catalano, Alberto; Sánchez, Maria-Jose; Masala, Giovanna; Olsen, Anja; Guevara, Marcela; Key, Timothy J; Gunter, Marc J; Agnoli, Claudia; Travis, Ruth C; Katzke, Verena; Smith-Byrne, Karl; Schulze, Matthias B

doi:10.1002/ijc.35208

Items
Marc 21

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041	_	_	\|a English
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100	1	_	\|a Grenville, Zoe S \|0 0000-0002-8185-5929 \|b 0
245	_	_	\|a Perturbations in the blood metabolome up to a decade before prostate cancer diagnosis in 4387 matched case-control sets from the European Prospective Investigation into Cancer and Nutrition.
260	_	_	\|a Bognor Regis \|c 2025 \|b Wiley-Liss
336	7	_	\|a article \|2 DRIVER
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500	_	_	\|a 2025 Mar 1;156(5):943-952
520	_	_	\|a Measuring pre-diagnostic blood metabolites may help identify novel risk factors for prostate cancer. Using data from 4387 matched case-control pairs from the European Prospective Investigation into Cancer and Nutrition (EPIC) study, we investigated the associations of 148 individual metabolites and three previously defined metabolite patterns with prostate cancer risk. Metabolites were measured by liquid chromatography-mass spectrometry. Multivariable-adjusted conditional logistic regression was used to estimate the odds ratio per standard deviation increase in log metabolite concentration and metabolite patterns (OR1SD) for prostate cancer overall, and for advanced, high-grade, aggressive. We corrected for multiple testing using the Benjamini-Hochberg method. Overall, there were no associations between specific metabolites or metabolite patterns and overall, aggressive, or high-grade prostate cancer that passed the multiple testing threshold (padj <0.05). Six phosphatidylcholines (PCs) were inversely associated with advanced prostate cancer diagnosed at or within 10 years of blood collection. metabolite patterns 1 (64 PCs and three hydroxysphingomyelins) and 2 (two acylcarnitines, glutamate, ornithine, and taurine) were also inversely associated with advanced prostate cancer; when stratified by follow-up time, these associations were observed for diagnoses at or within 10 years of recruitment (OR1SD 0.80, 95% CI 0.66-0.96 and 0.76, 0.59-0.97, respectively) but were weaker after longer follow-up (0.95, 0.82-1.10 and 0.85, 0.67-1.06). Pattern 3 (8 lyso PCs) was associated with prostate cancer death (0.82, 0.68-0.98). Our results suggest that the plasma metabolite profile changes in response to the presence of prostate cancer up to a decade before detection of advanced-stage disease.
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650	_	7	\|a European prospective investigation into cancer and nutrition (EPIC) \|2 Other
650	_	7	\|a cancer biomarkers \|2 Other
650	_	7	\|a metabolomics \|2 Other
650	_	7	\|a prospective cohort \|2 Other
650	_	7	\|a prostate cancer \|2 Other
700	1	_	\|a Noor, Urwah \|b 1
700	1	_	\|a Rinaldi, Sabina \|b 2
700	1	_	\|a Gunter, Marc J \|b 3
700	1	_	\|a Ferrari, Pietro \|b 4
700	1	_	\|a Agnoli, Claudia \|b 5
700	1	_	\|a Amiano, Pilar \|b 6
700	1	_	\|a Catalano, Alberto \|0 0000-0003-2597-2060 \|b 7
700	1	_	\|a Chirlaque, María Dolores \|b 8
700	1	_	\|a Christakoudi, Sofia \|0 0000-0001-9219-4436 \|b 9
700	1	_	\|a Guevara, Marcela \|b 10
700	1	_	\|a Johansson, Matthias \|b 11
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700	1	_	\|a Masala, Giovanna \|b 14
700	1	_	\|a Olsen, Anja \|b 15
700	1	_	\|a Papier, Keren \|b 16
700	1	_	\|a Sánchez, Maria-Jose \|b 17
700	1	_	\|a Schulze, Matthias B \|b 18
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700	1	_	\|a Key, Timothy J \|b 24
700	1	_	\|a Smith-Byrne, Karl \|b 25
700	1	_	\|a Schmidt, Julie A \|0 0000-0002-7733-8750 \|b 26
700	1	_	\|a Travis, Ruth C \|b 27
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Library	Collection	CLSMajor	CLSMinor	Language	Author

Marc 21

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