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@ARTICLE{Xie:293969,
      author       = {H. Xie and M. Halimulati and Y. Dou and H. Zhang and X.
                      Jiang and L. Peng$^*$},
      title        = {{S}ystemic immune-inflammation states in {US} adults with
                      seropositivity to infectious pathogens: {A} nutrient-wide
                      association study.},
      journal      = {Journal of parenteral and enteral nutrition},
      volume       = {49},
      number       = {1},
      issn         = {0148-6071},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DKFZ-2024-02029},
      pages        = {94-102},
      year         = {2025},
      note         = {#LA:C070# / 2025 Jan;49(1):94-102},
      abstract     = {Limited understanding exists regarding the association
                      between daily total dietary nutrient intakes and
                      immune-inflammation states in US adults exposed to various
                      pathogens. This study sought to examine the correlation
                      between nutrient intakes and immune-inflammation indicators
                      and to assess their performance in distinguishing
                      immune-inflammation states.This study was derived from the
                      National Health and Nutrition Examination Survey (NHANES),
                      which included 33,804 participants aged 20 years or older
                      between 2005 and 2018. Multivariable linear regression and
                      restricted cubic spline regression were conducted to
                      evaluate the association between nutrient intakes and
                      immune-inflammation indicators. Receiver operating
                      characteristic curve analysis was performed to evaluate the
                      discriminatory performance of identified nutrients for
                      various immune-inflammation states measured by the systemic
                      immune-inflammation index (SII).Ten key nutrients were
                      significantly associated with immune-inflammation responses,
                      including calcium, saturated fatty acid (SFA) 4:0, SFA 6:0,
                      SFA 12:0, SFA 14:0, SFA 16:0, vitamin B2, total SFAs,
                      retinol, and lutein + zeaxanthin, which show potential as
                      dietary indicators. The area under the curve for
                      discriminating various immune-inflammation states was
                      improved by at least 0.03 compared with a model that
                      included only covariates, with all P values <0.05 in the
                      Delong tests, indicating a significant enhancement in model
                      performance.Ten nutrients, including calcium, various SFAs,
                      vitamin B2, retinol, and lutein + zeaxanthin, exhibit
                      significant association with SII and potential as dietary
                      indicators for distinguishing between different
                      immune-inflammation states in US adults with seropositivity
                      to various viruses.},
      keywords     = {dose‐response relationship (Other) /
                      immune‐inflammation status (Other) / nutrients (Other)},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39380423},
      doi          = {10.1002/jpen.2695},
      url          = {https://inrepo02.dkfz.de/record/293969},
}