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000294054 1001_ $$00000-0002-8614-2792$$aRosenau, Lorenz$$b0
000294054 245__ $$aBridging Data Models in Health Care With a Novel Intermediate Query Format for Feasibility Queries: Mixed Methods Study.
000294054 260__ $$aToronto$$b[Verlag nicht ermittelbar]$$c2024
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000294054 520__ $$aTo advance research with clinical data, it is essential to make access to the available data as fast and easy as possible for researchers, which is especially challenging for data from different source systems within and across institutions. Over the years, many research repositories and data standards have been created. One of these is the Fast Healthcare Interoperability Resources (FHIR) standard, used by the German Medical Informatics Initiative (MII) to harmonize and standardize data across university hospitals in Germany. One of the first steps to make these data available is to allow researchers to create feasibility queries to determine the data availability for a specific research question. Given the heterogeneity of different query languages to access different data across and even within standards such as FHIR (eg, CQL and FHIR Search), creating an intermediate query syntax for feasibility queries reduces the complexity of query translation and improves interoperability across different research repositories and query languages.This study describes the creation and implementation of an intermediate query syntax for feasibility queries and how it integrates into the federated German health research portal (Forschungsdatenportal Gesundheit) and the MII.We analyzed the requirements for feasibility queries and the feasibility tools that are currently available in research repositories. Based on this analysis, we developed an intermediate query syntax that can be easily translated into different research repository-specific query languages.The resulting Clinical Cohort Definition Language (CCDL) for feasibility queries combines inclusion criteria in a conjunctive normal form and exclusion criteria in a disjunctive normal form, allowing for additional filters like time or numerical restrictions. The inclusion and exclusion results are combined via an expression to specify feasibility queries. We defined a JSON schema for the CCDL, generated an ontology, and demonstrated the use and translatability of the CCDL across multiple studies and real-world use cases.We developed and evaluated a structured query syntax for feasibility queries and demonstrated its use in a real-world example as part of a research platform across 39 German university hospitals.
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000294054 650_7 $$2Other$$aCQL
000294054 650_7 $$2Other$$aFHIR
000294054 650_7 $$2Other$$aJSON
000294054 650_7 $$2Other$$aclinical research
000294054 650_7 $$2Other$$acohort definition
000294054 650_7 $$2Other$$adevelop
000294054 650_7 $$2Other$$adevelopment
000294054 650_7 $$2Other$$aeligibility criteria
000294054 650_7 $$2Other$$afeasibility
000294054 650_7 $$2Other$$ahealthcare interoperability
000294054 650_7 $$2Other$$aimplementation
000294054 650_7 $$2Other$$ainformatics
000294054 650_7 $$2Other$$aintermediate query format
000294054 650_7 $$2Other$$ainteroperability
000294054 650_7 $$2Other$$ainteroperable
000294054 650_7 $$2Other$$aontologies
000294054 650_7 $$2Other$$aontology
000294054 650_7 $$2Other$$aportal
000294054 650_7 $$2Other$$aportals
000294054 650_7 $$2Other$$aqueries
000294054 650_7 $$2Other$$aquery
000294054 650_2 $$2MeSH$$aFeasibility Studies
000294054 650_2 $$2MeSH$$aGermany
000294054 650_2 $$2MeSH$$aHumans
000294054 650_2 $$2MeSH$$aHealth Information Interoperability
000294054 650_2 $$2MeSH$$aInformation Storage and Retrieval: methods
000294054 7001_ $$00000-0001-7204-5329$$aGruendner, Julian$$b1
000294054 7001_ $$aKiel, Alexander$$b2
000294054 7001_ $$0P:(DE-He78)2d3f4184094dad9cd303bf5e059d31ba$$aKöhler, Thomas$$b3$$udkfz
000294054 7001_ $$00009-0007-9472-0293$$aSchaffer, Bastian$$b4
000294054 7001_ $$00000-0002-8260-8815$$aMajeed, Raphael W$$b5
000294054 773__ $$0PERI:(DE-600)2798261-0$$a10.2196/58541$$gVol. 12, p. e58541 - e58541$$pe58541 - e58541$$tJMIR medical informatics$$v12$$x2291-9694$$y2024
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