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000294061 1001_ $$aSherman, Mark E$$b0
000294061 245__ $$aPolygenic risk scores stratify breast cancer risk among women with benign breast disease.
000294061 260__ $$aOxford$$bOxford Univ. Press$$c2025
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000294061 520__ $$aMost breast biopsies are diagnosed as benign breast disease (BBD), with 1.5- to fourfold increased breast cancer (BC) risk. Apart from pathologic diagnoses of atypical hyperplasia, few factors aid in BC risk assessment of these patients. We assessed whether a 313-SNP polygenic risk score (PRS) stratifies risk of BBD patients.We pooled data from five Breast Cancer Association Consortium case-control studies (mean age = 59.9 years), including 6,706 cases and 8,488 controls. Using logistic regression, we estimated BC risk associations by self-reported BBD history and strata of PRS, with median PRS category among women without BBD as the referent. We assessed interactions and mediation of BBD and PRS with BC risk.BBD history was associated with increased BC risk (OR = 1.48, 95% CI: 1.37-1.60; p < .001). PRS increased BC risk, irrespective of BBD history (p-interaction = 0.48), with minimal evidence of mediation of either factor by the other. Women with BBD and PRS in the highest tertile had over 2-fold increased odds of BC (OR = 2.73, 95% CI: 2.41-3.09) and those with BBD and PRS in the lowest tertile experienced reduced BC risk (OR = 0.79, 95% CI: 0.70-0.91), compared to the reference group. Women with BBD and PRS in the highest decile had a 3.7- fold increase (95% CI: 3.00-4.61) compared to those with median PRS without BBD.BC risks are elevated among women with BBD and increase progressively with PRS, suggesting that optimal combinations of these factors may improve risk stratification.
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000294061 7001_ $$aWinham, Stacey J$$b1
000294061 7001_ $$aVierkant, Robert A$$b2
000294061 7001_ $$aMccauley, Bryan M$$b3
000294061 7001_ $$aScott, Christopher G$$b4
000294061 7001_ $$aSchrup, Sarah$$b5
000294061 7001_ $$aGaudet, Mia M$$b6
000294061 7001_ $$aTroester, Melissa A$$b7
000294061 7001_ $$aPruthi, Sandhya$$b8
000294061 7001_ $$aRadisky, Derek C$$b9
000294061 7001_ $$aDegnim, Amy C$$b10
000294061 7001_ $$aCouch, Fergus J$$b11
000294061 7001_ $$aBolla, Manjeet K$$b12
000294061 7001_ $$aWang, Qin$$b13
000294061 7001_ $$aDennis, Joe$$b14
000294061 7001_ $$aMichailidou, Kyriaki$$b15
000294061 7001_ $$0P:(DE-HGF)0$$aGuenel, Pascal$$b16
000294061 7001_ $$0P:(DE-HGF)0$$aTruong, Therese$$b17
000294061 7001_ $$0P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aChang-Claude, Jenny$$b18$$udkfz
000294061 7001_ $$aObi, Nadia$$b19
000294061 7001_ $$aAronson, Kristan J$$b20
000294061 7001_ $$aMurphy, Rachel$$b21
000294061 7001_ $$aGarcia-Closas, Montserrat$$b22
000294061 7001_ $$aChanock, Stephen$$b23
000294061 7001_ $$aAhearn, Thomas$$b24
000294061 7001_ $$aYang, Xiaohong$$b25
000294061 7001_ $$aDunning, Alison M$$b26
000294061 7001_ $$aMavaddat, Nasim$$b27
000294061 7001_ $$aPharoah, Paul D P$$b28
000294061 7001_ $$aEaston, Douglas F$$b29
000294061 7001_ $$aVachon, Celine M$$b30
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