% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Remke:294069,
      author       = {M. Remke$^*$ and T. Groll and T. Metzler and E. Urbauer and
                      J. Kövilein and T. Schnalzger and J. Ruland and D. Haller
                      and K. Steiger$^*$},
      title        = {{H}istomorphological scoring of murine colitis models: {A}
                      practical guide for the evaluation of colitis and
                      colitis-associated cancer.},
      journal      = {Experimental and molecular pathology},
      volume       = {140},
      issn         = {0014-4800},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2024-02090},
      pages        = {104938},
      year         = {2024},
      abstract     = {Histomorphology is a powerful and cost-efficient tool for
                      evaluating inflammatory and neoplastic conditions.
                      Inflammatory bowel disease (IBD) is a widespread condition
                      with globally rising incidences, and a lot of research is
                      done to better understand the pathogenesis of IBD and to
                      identify potential therapeutic approaches. However,
                      standardized and reproducible scores for the
                      histomorphological evaluation of murine IBD models are
                      lacking. Therefore, we aimed to develop an easy-to-use and
                      reproducible score for standardized assessment of colitis
                      and associated cancer models.In this study, samples from
                      three different colitis models with and without associated
                      cancer formation were analyzed to develop a universal,
                      robust, and reproducible score for the grading of murine
                      colitis models using the following three parameters: 1.
                      Extent of leucocyte infiltration, 2. Tissue damage, 3.
                      Architectural disruption of the mucosa.A scoring system was
                      established for different kinds of colitis models
                      (genetically induced enterocolitis, genetically induced
                      metabolic injury, and chemically induced colitis-associated
                      cancer) and all stages of the disease, from mild
                      inflammatory changes to severe inflammation with neoplastic
                      changes as the extreme extent of IBD. The scoring scheme is
                      easy to use, can easily be learned, and proves to have a
                      high interrater reliability.We propose a robust histological
                      scoring system for the assessment of murine colitis and
                      colitis-associated cancer models, giving more researchers
                      access to conclusive and reliable histological assessment.},
      keywords     = {Animal models (Other) / Experimental pathology (Other) /
                      Inflammation (Other) / Inflammatory bowel diseases (Other)},
      cin          = {MU01},
      ddc          = {610},
      cid          = {I:(DE-He78)MU01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39418944},
      doi          = {10.1016/j.yexmp.2024.104938},
      url          = {https://inrepo02.dkfz.de/record/294069},
}