TY  - JOUR
AU  - Lim-Fat, Mary Jane
AU  - Bennett, Julie
AU  - Ostrom, Quinn
AU  - Touat, Mehdi
AU  - Franceschi, Enrico
AU  - Schulte, Jessica
AU  - Bindra, Ranjit S
AU  - Fangusaro, Jason
AU  - Dhall, Girish
AU  - Nicholson, James
AU  - Jackson, Sadhana
AU  - Davidson, Tom Belle
AU  - Calaminus, Gabriele
AU  - Robinson, Giles
AU  - Whittle, James R
AU  - Hau, Peter
AU  - Ramaswamy, Vijay
AU  - Pajtler, Kristian
AU  - Rudà, Roberta
AU  - Foreman, Nicholas K
AU  - Hervey-Jumper, Shawn L
AU  - Das, Sunit
AU  - Dirks, Peter
AU  - Bi, Wenya Linda
AU  - Huang, Annie
AU  - Merchant, Thomas E
AU  - Fouladi, Maryam
AU  - Aldape, Kenneth
AU  - Van den Bent, Martin J
AU  - Packer, Roger J
AU  - Miller, Julie J
AU  - Reardon, David A
AU  - Chang, Susan M
AU  - Haas-Kogan, Daphne
AU  - Tabori, Uri
AU  - Hawkins, Cynthia
AU  - Monje, Michelle
AU  - Wen, Patrick Y
AU  - Bouffet, Eric
AU  - Yeo, Kee Kiat
TI  - Central nervous system tumors in adolescents and young adults: A Society for Neuro-Oncology consensus review on diagnosis, management, and future directions.
JO  - Neuro-Oncology
VL  - 27
IS  - 1
SN  - 1522-8517
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DKFZ-2024-02125
SP  - 13–32
PY  - 2025
N1  - Volume 27, Issue 1, January 2025, Pages 13–32
AB  - Adolescents and young adults (AYAs; ages 15-39 years) are a vulnerable population facing challenges in oncological care, including access to specialized care, transition of care, unique tumor biology, and poor representation in clinical trials. Brain tumors are the second most common tumor type in AYA, with malignant brain tumors being the most common cause of cancer-related death. The 2021 WHO Classification for central nervous system (CNS) Tumors highlights the importance of integrated molecular characterization with histologic diagnosis in several tumors relevant to the AYA population. In this position paper from the Society for Neuro-Oncology (SNO), the diagnosis and management of CNS tumors in AYA is reviewed, focusing on the most common tumor types in this population, namely glioma, medulloblastoma, ependymoma, and CNS germ cell tumor. Current challenges and future directions specific to AYA are also highlighted. Finally, possible solutions to address barriers in the care of AYA patients are discussed, emphasizing the need for multidisciplinary and collaborative approaches that span the pediatric and adult paradigms of care, and incorporating advanced molecular testing, targeted therapy, and AYA-centered care.
KW  - adolescents and young adults (Other)
KW  - brain tumors (Other)
KW  - precision medicine (Other)
KW  - survivorship (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39441704
DO  - DOI:10.1093/neuonc/noae186
UR  - https://inrepo02.dkfz.de/record/294122
ER  -