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@ARTICLE{LimFat:294122,
author = {M. J. Lim-Fat and J. Bennett and Q. Ostrom and M. Touat and
E. Franceschi and J. Schulte and R. S. Bindra and J.
Fangusaro and G. Dhall and J. Nicholson and S. Jackson and
T. B. Davidson and G. Calaminus and G. Robinson and J. R.
Whittle and P. Hau and V. Ramaswamy and K. Pajtler$^*$ and
R. Rudà and N. K. Foreman and S. L. Hervey-Jumper and S.
Das and P. Dirks and W. L. Bi and A. Huang and T. E.
Merchant and M. Fouladi and K. Aldape and M. J. Van den Bent
and R. J. Packer and J. J. Miller and D. A. Reardon and S.
M. Chang and D. Haas-Kogan and U. Tabori and C. Hawkins and
M. Monje and P. Y. Wen and E. Bouffet and K. K. Yeo},
title = {{C}entral nervous system tumors in adolescents and young
adults: {A} {S}ociety for {N}euro-{O}ncology consensus
review on diagnosis, management, and future directions.},
journal = {Neuro-Oncology},
volume = {27},
number = {1},
issn = {1522-8517},
address = {Oxford},
publisher = {Oxford Univ. Press},
reportid = {DKFZ-2024-02125},
pages = {13–32},
year = {2025},
note = {Volume 27, Issue 1, January 2025, Pages 13–32},
abstract = {Adolescents and young adults (AYAs; ages 15-39 years) are a
vulnerable population facing challenges in oncological care,
including access to specialized care, transition of care,
unique tumor biology, and poor representation in clinical
trials. Brain tumors are the second most common tumor type
in AYA, with malignant brain tumors being the most common
cause of cancer-related death. The 2021 WHO Classification
for central nervous system (CNS) Tumors highlights the
importance of integrated molecular characterization with
histologic diagnosis in several tumors relevant to the AYA
population. In this position paper from the Society for
Neuro-Oncology (SNO), the diagnosis and management of CNS
tumors in AYA is reviewed, focusing on the most common tumor
types in this population, namely glioma, medulloblastoma,
ependymoma, and CNS germ cell tumor. Current challenges and
future directions specific to AYA are also highlighted.
Finally, possible solutions to address barriers in the care
of AYA patients are discussed, emphasizing the need for
multidisciplinary and collaborative approaches that span the
pediatric and adult paradigms of care, and incorporating
advanced molecular testing, targeted therapy, and
AYA-centered care.},
subtyp = {Review Article},
keywords = {adolescents and young adults (Other) / brain tumors (Other)
/ precision medicine (Other) / survivorship (Other)},
cin = {B062 / HD01},
ddc = {610},
cid = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331},
pnm = {312 - Funktionelle und strukturelle Genomforschung
(POF4-312)},
pid = {G:(DE-HGF)POF4-312},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:39441704},
doi = {10.1093/neuonc/noae186},
url = {https://inrepo02.dkfz.de/record/294122},
}