000294306 001__ 294306
000294306 005__ 20241028182244.0
000294306 0247_ $$2doi$$a10.3390/cancers16203528
000294306 0247_ $$2pmid$$apmid:39456621
000294306 0247_ $$2pmc$$apmc:PMC11506215
000294306 037__ $$aDKFZ-2024-02139
000294306 041__ $$aEnglish
000294306 082__ $$a610
000294306 1001_ $$aZeber-Lubecka, Natalia$$b0
000294306 245__ $$aDysbiosis of the Upper Gastrointestinal Tract in Head-and-Neck Cancer Survivors: A Pilot Study Using the Capsule Sponge Device.
000294306 260__ $$aBasel$$bMDPI$$c2024
000294306 3367_ $$2DRIVER$$aarticle
000294306 3367_ $$2DataCite$$aOutput Types/Journal article
000294306 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1730124974_22133
000294306 3367_ $$2BibTeX$$aARTICLE
000294306 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000294306 3367_ $$00$$2EndNote$$aJournal Article
000294306 520__ $$aA non-endoscopic capsule-sponge device allows sampling the entire length of the esophagus. Here, we compared microbiomes of the oral cavity, esophagus, and gastric corpus collected by oral swab, capsule-sponge device, and endoscopic biopsy, respectively, in patients representing three distinct risk profiles for esophageal squamous cell carcinoma (ESCC).The study enrolled 11 patients with esophageal squamous intraepithelial neoplasia, 21 patients after curative treatment for head and neck squamous cell cancer (HNSCC) (HNSCC survivors), and 40 patients with functional dyspeptic (FD) symptoms. Microbial genomic DNA was analyzed using 16S rRNA gene amplicon sequencing.The Shannon index of the capsule-sponge sample microbiota was significantly higher in FD group than in patients after treatment for HNSCC, and the Chao index of gastric samples differed between HNSCC survivors and FD patients. Analysis of the β-diversity of FD patients, HNSCC, and esophageal squamous intraepithelial neoplasia showed that different genera formed at each location. The abundance of 205, 116, and 9 genera differed between FD patients and HNSCC survivors in the gastric, capsule-sponge, and oral samples, respectively; 33 genera differed between the FD group and patients with esophageal squamous intraepithelial neoplasia in capsule-sponge samples.The bacterial communities of the upper digestive tract were clustered according to the anatomic site. Despite substantial differences in gastric and esophageal microbiota samples between FD patients and HNSCC survivors, the microbial members and diversity showed small differences between FD patients and those with esophageal squamous intraepithelial neoplasia. It remains unclear whether gastric and esophageal dysbiosis is associated with or is a consequence of treatment for HNSCC.
000294306 536__ $$0G:(DE-HGF)POF4-313$$a313 - Krebsrisikofaktoren und Prävention (POF4-313)$$cPOF4-313$$fPOF IV$$x0
000294306 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000294306 650_7 $$2Other$$acapsule-sponge device
000294306 650_7 $$2Other$$aearly esophageal squamous cell carcinoma (ESCC)
000294306 650_7 $$2Other$$aesophageal squamous intraepithelial neoplasia
000294306 650_7 $$2Other$$ahead and neck squamous cell cancer (HNSCC)
000294306 650_7 $$2Other$$amicrobial dysbiosis
000294306 7001_ $$aKulecka, Maria$$b1
000294306 7001_ $$aDabrowska, Michalina$$b2
000294306 7001_ $$aKluska, Anna$$b3
000294306 7001_ $$00000-0001-8372-8002$$aPiątkowska, Magdalena$$b4
000294306 7001_ $$aTurkot, Maryla Helena$$b5
000294306 7001_ $$aPilonis, Nastazja Dagny$$b6
000294306 7001_ $$00000-0002-7799-4379$$aYusuf, Aisha$$b7
000294306 7001_ $$0P:(DE-He78)5eecfbb3a55c32d69c08f67104c5c62b$$aNowicki-Osuch, Karol$$b8$$udkfz
000294306 7001_ $$00000-0003-3447-7328$$aMikula, Michal$$b9
000294306 7001_ $$aOstrowski, Jerzy$$b10
000294306 773__ $$0PERI:(DE-600)2527080-1$$a10.3390/cancers16203528$$gVol. 16, no. 20, p. 3528 -$$n20$$p3528$$tCancers$$v16$$x2072-6694$$y2024
000294306 909CO $$ooai:inrepo02.dkfz.de:294306$$pVDB
000294306 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)5eecfbb3a55c32d69c08f67104c5c62b$$aDeutsches Krebsforschungszentrum$$b8$$kDKFZ
000294306 9131_ $$0G:(DE-HGF)POF4-313$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vKrebsrisikofaktoren und Prävention$$x0
000294306 9141_ $$y2024
000294306 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bCANCERS : 2022$$d2023-10-26
000294306 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-10-26
000294306 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-10-26
000294306 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2023-10-26
000294306 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2023-07-31T16:07:06Z
000294306 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2023-07-31T16:07:06Z
000294306 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Anonymous peer review$$d2023-07-31T16:07:06Z
000294306 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ$$d2023-07-31T16:07:06Z
000294306 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2023-10-26
000294306 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2023-10-26
000294306 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-10-26
000294306 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2023-10-26
000294306 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2023-10-26
000294306 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-10-26
000294306 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2023-10-26
000294306 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2023-10-26
000294306 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bCANCERS : 2022$$d2023-10-26
000294306 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2023-10-26
000294306 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2023-10-26
000294306 9201_ $$0I:(DE-He78)C150-20160331$$kC150$$lNWG Tumorgenese und molekulare Krebsprävention$$x0
000294306 980__ $$ajournal
000294306 980__ $$aVDB
000294306 980__ $$aI:(DE-He78)C150-20160331
000294306 980__ $$aUNRESTRICTED