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@ARTICLE{ZeberLubecka:294306,
      author       = {N. Zeber-Lubecka and M. Kulecka and M. Dabrowska and A.
                      Kluska and M. Piątkowska and M. H. Turkot and N. D. Pilonis
                      and A. Yusuf and K. Nowicki-Osuch$^*$ and M. Mikula and J.
                      Ostrowski},
      title        = {{D}ysbiosis of the {U}pper {G}astrointestinal {T}ract in
                      {H}ead-and-{N}eck {C}ancer {S}urvivors: {A} {P}ilot {S}tudy
                      {U}sing the {C}apsule {S}ponge {D}evice.},
      journal      = {Cancers},
      volume       = {16},
      number       = {20},
      issn         = {2072-6694},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2024-02139},
      pages        = {3528},
      year         = {2024},
      abstract     = {A non-endoscopic capsule-sponge device allows sampling the
                      entire length of the esophagus. Here, we compared
                      microbiomes of the oral cavity, esophagus, and gastric
                      corpus collected by oral swab, capsule-sponge device, and
                      endoscopic biopsy, respectively, in patients representing
                      three distinct risk profiles for esophageal squamous cell
                      carcinoma (ESCC).The study enrolled 11 patients with
                      esophageal squamous intraepithelial neoplasia, 21 patients
                      after curative treatment for head and neck squamous cell
                      cancer (HNSCC) (HNSCC survivors), and 40 patients with
                      functional dyspeptic (FD) symptoms. Microbial genomic DNA
                      was analyzed using 16S rRNA gene amplicon sequencing.The
                      Shannon index of the capsule-sponge sample microbiota was
                      significantly higher in FD group than in patients after
                      treatment for HNSCC, and the Chao index of gastric samples
                      differed between HNSCC survivors and FD patients. Analysis
                      of the β-diversity of FD patients, HNSCC, and esophageal
                      squamous intraepithelial neoplasia showed that different
                      genera formed at each location. The abundance of 205, 116,
                      and 9 genera differed between FD patients and HNSCC
                      survivors in the gastric, capsule-sponge, and oral samples,
                      respectively; 33 genera differed between the FD group and
                      patients with esophageal squamous intraepithelial neoplasia
                      in capsule-sponge samples.The bacterial communities of the
                      upper digestive tract were clustered according to the
                      anatomic site. Despite substantial differences in gastric
                      and esophageal microbiota samples between FD patients and
                      HNSCC survivors, the microbial members and diversity showed
                      small differences between FD patients and those with
                      esophageal squamous intraepithelial neoplasia. It remains
                      unclear whether gastric and esophageal dysbiosis is
                      associated with or is a consequence of treatment for HNSCC.},
      keywords     = {capsule-sponge device (Other) / early esophageal squamous
                      cell carcinoma (ESCC) (Other) / esophageal squamous
                      intraepithelial neoplasia (Other) / head and neck squamous
                      cell cancer (HNSCC) (Other) / microbial dysbiosis (Other)},
      cin          = {C150},
      ddc          = {610},
      cid          = {I:(DE-He78)C150-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39456621},
      pmc          = {pmc:PMC11506215},
      doi          = {10.3390/cancers16203528},
      url          = {https://inrepo02.dkfz.de/record/294306},
}