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@ARTICLE{Kemp:294315,
author = {T. J. Kemp and G. Panicker and C. Eklund and J. Nie and Y.
Wang and S. Beddows and P. Rigsby and W. Huang and J.
Dillner and E. R. Unger and L. A. Pinto and D. E. Wilkinson},
collaboration = {c. s. participants},
othercontributors = {P. Licciardi and Z. Q. Toh and M. Müller$^*$ and T. M. C.
Rajanathan and S. Li and N. Xia and G. Liu and C. Zhou and
L. Zhou and N. Xu and K. Panwar and D. Galloway and J.
Carter},
title = {{WHO} {I}nternational {S}tandards for antibodies to {HPV}6
{HPV}11 {HPV}31 {HPV}33 {HPV}45 {HPV}52 and {HPV}58.},
journal = {npj vaccines},
volume = {9},
number = {1},
issn = {2059-0105},
address = {[London]},
publisher = {Nature Publishing Group},
reportid = {DKFZ-2024-02148},
pages = {165},
year = {2024},
abstract = {Previously established World Health Organization (WHO)
International Standards (IS) for anti-HPV16 and HPV18
antibodies are used to harmonize results across human
papillomavirus (HPV) serology assays. Here, we present an
international collaborative study to establish ISs for
antibodies against HPV6 (NIBSC code 19/298), HPV11 (20/174),
HPV31 (20/176), HPV33 (19/290), HPV45 (20/178), HPV52
(19/296) and HPV58 (19/300). The candidate standards were
prepared using sera from naturally infected individuals.
Each candidate was shown to be monospecific for reactivity
against its indicated HPV type except for the HPV11
candidate, which was also reactive against other types.
Expression of antibody levels relative to the relevant
candidate IS reduced inter-laboratory variation allowing
greater comparability between laboratories. Based on these
results, the WHO Expert Committee on Biological
Standardization established each of the 7 candidates as the
1st IS for antiserum to its indicated HPV type for use in
the standardization of HPV pseudovirion-based neutralization
and antibody-binding assays.},
cin = {D335},
ddc = {610},
cid = {I:(DE-He78)D335-20160331},
pnm = {314 - Immunologie und Krebs (POF4-314)},
pid = {G:(DE-HGF)POF4-314},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:39256440},
pmc = {pmc:PMC11387505},
doi = {10.1038/s41541-024-00949-2},
url = {https://inrepo02.dkfz.de/record/294315},
}