TY  - JOUR
AU  - Castro-Espin, Carlota
AU  - Cairat, Manon
AU  - Navionis, Anne-Sophie
AU  - Dahm, Christina C
AU  - Antoniussen, Christian S
AU  - Tjønneland, Anne
AU  - Mellemkjær, Lene
AU  - Mancini, Francesca Romana
AU  - Hajji-Louati, Mariem
AU  - Severi, Gianluca
AU  - Le Cornet, Charlotte
AU  - Kaaks, Rudolf
AU  - Schulze, Matthias B
AU  - Masala, Giovanna
AU  - Agnoli, Claudia
AU  - Sacerdote, Carlotta
AU  - Crous-Bou, Marta
AU  - Sánchez, Maria-Jose
AU  - Amiano, Pilar
AU  - Chirlaque, María-Dolores
AU  - Guevara, Marcela
AU  - Smith-Byrne, Karl
AU  - Heath, Alicia K
AU  - Christakoudi, Sofia
AU  - Gunter, Marc J
AU  - Rinaldi, Sabina
AU  - Agudo, Antonio
AU  - Dossus, Laure
TI  - Prognostic role of pre-diagnostic circulating inflammatory biomarkers in breast cancer survival: evidence from the EPIC cohort study.
JO  - British journal of cancer
VL  - 131
IS  - 9
SN  - 0007-0920
CY  - Edinburgh
PB  - Nature Publ. Group
M1  - DKFZ-2024-02193
SP  - 1496 - 1505
PY  - 2024
AB  - Inflammation influences tumour progression and cancer prognosis, but its role preceding breast cancer (BC) and its prognostic implications remain inconclusive.We studied pre-diagnostic plasma inflammatory biomarkers in 1538 women with BC from the EPIC study. Cox proportional hazards models assessed their relationship with all-cause and BC-specific mortality, adjusting for tumour characteristics and lifestyle factors.Over a 7-year follow-up after diagnosis, 229 women died, 163 from BC. Elevated IL-6 levels were associated with increased all-cause mortality risk (HR1-SD 1.25, 95
KW  - Humans
KW  - Female
KW  - Breast Neoplasms: mortality
KW  - Breast Neoplasms: blood
KW  - Breast Neoplasms: diagnosis
KW  - Breast Neoplasms: pathology
KW  - Middle Aged
KW  - Prognosis
KW  - Inflammation: blood
KW  - Inflammation: mortality
KW  - Biomarkers, Tumor: blood
KW  - Interleukin-6: blood
KW  - Aged
KW  - Postmenopause: blood
KW  - Cohort Studies
KW  - Interleukin-10: blood
KW  - Adult
KW  - Tumor Necrosis Factor-alpha: blood
KW  - Proportional Hazards Models
KW  - Biomarkers, Tumor (NLM Chemicals)
KW  - Interleukin-6 (NLM Chemicals)
KW  - Interleukin-10 (NLM Chemicals)
KW  - Tumor Necrosis Factor-alpha (NLM Chemicals)
KW  - IL6 protein, human (NLM Chemicals)
KW  - IL10 protein, human (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:39342063
DO  - DOI:10.1038/s41416-024-02858-6
UR  - https://inrepo02.dkfz.de/record/294360
ER  -