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@ARTICLE{CastroEspin:294360,
author = {C. Castro-Espin and M. Cairat and A.-S. Navionis and C. C.
Dahm and C. S. Antoniussen and A. Tjønneland and L.
Mellemkjær and F. R. Mancini and M. Hajji-Louati and G.
Severi and C. Le Cornet$^*$ and R. Kaaks$^*$ and M. B.
Schulze and G. Masala and C. Agnoli and C. Sacerdote and M.
Crous-Bou and M.-J. Sánchez and P. Amiano and M.-D.
Chirlaque and M. Guevara and K. Smith-Byrne and A. K. Heath
and S. Christakoudi and M. J. Gunter and S. Rinaldi and A.
Agudo and L. Dossus},
title = {{P}rognostic role of pre-diagnostic circulating
inflammatory biomarkers in breast cancer survival: evidence
from the {EPIC} cohort study.},
journal = {British journal of cancer},
volume = {131},
number = {9},
issn = {0007-0920},
address = {Edinburgh},
publisher = {Nature Publ. Group},
reportid = {DKFZ-2024-02193},
pages = {1496 - 1505},
year = {2024},
abstract = {Inflammation influences tumour progression and cancer
prognosis, but its role preceding breast cancer (BC) and its
prognostic implications remain inconclusive.We studied
pre-diagnostic plasma inflammatory biomarkers in 1538 women
with BC from the EPIC study. Cox proportional hazards models
assessed their relationship with all-cause and BC-specific
mortality, adjusting for tumour characteristics and
lifestyle factors.Over a 7-year follow-up after diagnosis,
229 women died, 163 from BC. Elevated IL-6 levels were
associated with increased all-cause mortality risk (HR1-SD
1.25, $95\%$ CI 1.07-1.47). Among postmenopausal, IL-6 was
associated with higher all-cause (HR1-SD 1.41, $95\%$ CI
1.18-1.69) and BC-specific mortality (HR1-SD 1.31, $95\%$ CI
1.03-1.66), (PHeterogeneity (pre/postmenopausal) < 0.05 for
both), while IL-10 and TNFα were associated with all-cause
mortality only (HR1-SD 1.19, $95\%$ CI 1.02-1.40 and HR1-SD
1.28, $95\%$ CI 1.06-1.56). Among ER+PR+, IL-10 was
associated with all-cause and BC-specific mortality (HR1-SD
1.35, $95\%$ CI 1.10-1.65 and HR1-SD 1.42 $95\%$ CI
1.08-1.86), while TNF-α was associated with all-cause
mortality in HER2- (HR1-SD 1.31, $95\%$ CI 1.07-1.61). An
inflammatory score predicted higher all-cause mortality,
especially in postmenopausal women (HR1-SD 1.30, $95\%$ CI
1.07-1.58).Higher pre-diagnosis IL-6 levels suggest poorer
long-term survival among BC survivors. In postmenopausal
survivors, elevated IL-6, IL-10, and TNFα and inflammatory
scores seem to predict all-cause mortality.},
keywords = {Humans / Female / Breast Neoplasms: mortality / Breast
Neoplasms: blood / Breast Neoplasms: diagnosis / Breast
Neoplasms: pathology / Middle Aged / Prognosis /
Inflammation: blood / Inflammation: mortality / Biomarkers,
Tumor: blood / Interleukin-6: blood / Aged / Postmenopause:
blood / Cohort Studies / Interleukin-10: blood / Adult /
Tumor Necrosis Factor-alpha: blood / Proportional Hazards
Models / Biomarkers, Tumor (NLM Chemicals) / Interleukin-6
(NLM Chemicals) / Interleukin-10 (NLM Chemicals) / Tumor
Necrosis Factor-alpha (NLM Chemicals) / IL6 protein, human
(NLM Chemicals) / IL10 protein, human (NLM Chemicals)},
cin = {C020},
ddc = {610},
cid = {I:(DE-He78)C020-20160331},
pnm = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
pid = {G:(DE-HGF)POF4-313},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:39342063},
doi = {10.1038/s41416-024-02858-6},
url = {https://inrepo02.dkfz.de/record/294360},
}