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000294426 1001_ $$aSobas, Marta Anna$$b0
000294426 245__ $$aOutcomes with intensive treatment for acute myeloid leukemia: an analysis of two decades of data from the HARMONY Alliance.
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000294426 500__ $$a2025 May 1;110(5):1126-1140
000294426 520__ $$aSince 2017, targeted therapies combined with conventional intensive chemotherapy have started to improve outcome of patients with acute myeloid leukemia (AML). However, even before these innovations outcomes with intensive chemotherapy have improved, which has not yet been extensively studied. Thus, we used a large pan-European multicenter dataset of the HARMONY Alliance to evaluate treatment-time dependent outcomes over two decades. In 5359 AML patients, we compared the impact of intensive induction therapy on outcome over four consecutive 5-year calendar periods from 1997 to 2016. During that time, the 5- year survival of AML patients improved significantly, also across different genetic risk groups. In particular, the 60-day mortality rate has dropped from 13.0% to 4.7% over time. The independent effect of calendar periods on outcome was confirmed in multivariate models. Improvements were documented both for patients.
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000294426 7001_ $$aTurki, Amin T$$b1
000294426 7001_ $$aRamiro, Angela Villaverde$$b2
000294426 7001_ $$aSánchez, Alberto Hernández$$b3
000294426 7001_ $$aElicegui, Javier Martinez$$b4
000294426 7001_ $$aGonzález, Teresa$$b5
000294426 7001_ $$aMelchor, Raúl Azibeiro$$b6
000294426 7001_ $$aAbáigar, María$$b7
000294426 7001_ $$aTur, Laura$$b8
000294426 7001_ $$aDall'Olio, Daniele$$b9
000294426 7001_ $$aSträng, Eric$$b10
000294426 7001_ $$aTettero, Jesse M$$b11
000294426 7001_ $$aCastellani, Gastone$$b12
000294426 7001_ $$0P:(DE-He78)e15dfa1260625c69d6690a197392a994$$aBenner, Axel$$b13$$udkfz
000294426 7001_ $$aDöhner, Konstanze$$b14
000294426 7001_ $$aThiede, Christian$$b15
000294426 7001_ $$aMetzeler, Klaus H$$b16
000294426 7001_ $$aHaferlach, Torsten$$b17
000294426 7001_ $$0P:(DE-HGF)0$$aDamm, Frederik$$b18
000294426 7001_ $$aAyala, Rosa$$b19
000294426 7001_ $$aMartínez-López, Joaquín$$b20
000294426 7001_ $$aMills, Ken I$$b21
000294426 7001_ $$aSierra, Jorge$$b22
000294426 7001_ $$aLehmann, Sören$$b23
000294426 7001_ $$aPorta, Matteo G Della$$b24
000294426 7001_ $$aMayer, Jiri$$b25
000294426 7001_ $$aReinhardt, Dirk$$b26
000294426 7001_ $$aMedina, Rubén Villoria$$b27
000294426 7001_ $$aSchulze-Rath, Renate$$b28
000294426 7001_ $$aBarbus, Martje$$b29
000294426 7001_ $$aHernández-Rivas, Jesús María$$b30
000294426 7001_ $$aHuntly, Brian J P$$b31
000294426 7001_ $$aOssenkoppele, Gert$$b32
000294426 7001_ $$aDöhner, Hartmut$$b33
000294426 7001_ $$0P:(DE-HGF)0$$aBullinger, Lars$$b34
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