TY  - JOUR
AU  - Sobas, Marta Anna
AU  - Turki, Amin T
AU  - Ramiro, Angela Villaverde
AU  - Sánchez, Alberto Hernández
AU  - Elicegui, Javier Martinez
AU  - González, Teresa
AU  - Melchor, Raúl Azibeiro
AU  - Abáigar, María
AU  - Tur, Laura
AU  - Dall'Olio, Daniele
AU  - Sträng, Eric
AU  - Tettero, Jesse M
AU  - Castellani, Gastone
AU  - Benner, Axel
AU  - Döhner, Konstanze
AU  - Thiede, Christian
AU  - Metzeler, Klaus H
AU  - Haferlach, Torsten
AU  - Damm, Frederik
AU  - Ayala, Rosa
AU  - Martínez-López, Joaquín
AU  - Mills, Ken I
AU  - Sierra, Jorge
AU  - Lehmann, Sören
AU  - Porta, Matteo G Della
AU  - Mayer, Jiri
AU  - Reinhardt, Dirk
AU  - Medina, Rubén Villoria
AU  - Schulze-Rath, Renate
AU  - Barbus, Martje
AU  - Hernández-Rivas, Jesús María
AU  - Huntly, Brian J P
AU  - Ossenkoppele, Gert
AU  - Döhner, Hartmut
AU  - Bullinger, Lars
TI  - Outcomes with intensive treatment for acute myeloid leukemia: an analysis of two decades of data from the HARMONY Alliance.
JO  - Haematologica
VL  - 110
IS  - 5
SN  - 0390-6078
CY  - Pavia
PB  - Ferrata Storti Foundation
M1  - DKFZ-2024-02255
SP  - 1126-1140
PY  - 2025
N1  - 2025 May 1;110(5):1126-1140
AB  - Since 2017, targeted therapies combined with conventional intensive chemotherapy have started to improve outcome of patients with acute myeloid leukemia (AML). However, even before these innovations outcomes with intensive chemotherapy have improved, which has not yet been extensively studied. Thus, we used a large pan-European multicenter dataset of the HARMONY Alliance to evaluate treatment-time dependent outcomes over two decades. In 5359 AML patients, we compared the impact of intensive induction therapy on outcome over four consecutive 5-year calendar periods from 1997 to 2016. During that time, the 5- year survival of AML patients improved significantly, also across different genetic risk groups. In particular, the 60-day mortality rate has dropped from 13.0
LB  - PUB:(DE-HGF)16
C6  - pmid:39506894
DO  - DOI:10.3324/haematol.2024.285805
UR  - https://inrepo02.dkfz.de/record/294426
ER  -