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001     294445
005     20241113182502.0
037 _ _ |a DKFZ-2024-02270
041 _ _ |a English
100 1 _ |0 P:(DE-He78)2a877d9e575a12fba128c39bc22580ec
|a Daugelaite, Klaudija
|b 0
|g female
|u dkfz
245 _ _ |a Regulation of hormonal stimulation and ageing in female reproductive tract
260 _ _ |c 2024
300 _ _ |a 104 p.
336 7 _ |2 DataCite
|a Output Types/Dissertation
336 7 _ |2 ORCID
|a DISSERTATION
336 7 _ |2 BibTeX
|a PHDTHESIS
336 7 _ |0 2
|2 EndNote
|a Thesis
336 7 _ |0 PUB:(DE-HGF)11
|2 PUB:(DE-HGF)
|a Dissertation / PhD Thesis
|b phd
|m phd
|s 1731507035_8013
336 7 _ |2 DRIVER
|a doctoralThesis
502 _ _ |a Dissertation, Universität Heidelberg, 2024
|b Dissertation
|c Universität Heidelberg
|d 2024
|g Fakultät für Biowissenschaften
|o 2024-11-11
520 _ _ |a In this thesis, I present four scientific projects that I lead or co-lead during my thesis, each interrogating different aspects of regulation within the female reproductive tract. The first project addresses critical gaps in our understanding of oocyte and granulosa cell interactions within cumulus-oocyte complexes (COCs) in the context of superovulation and ageing. I adapted developmental biology techniques to enable precise comparisons between individually tracked oocyte-granulosa cell pairs and naturally aged COCs. Additionally, I designed a prospective mouse IVF model to non-invasively predict embryo development trajectory using granulosa cell transcriptomes, addressing limitations of retrospective studies. The second project explores the evolutionary transcriptional divergence of oocytes across different mouse species, contributing to our understanding of oocyte evolution - a field predominantly focused on male gametes. Preliminary results suggest nuanced patterns of transcriptional divergence among species. In the third project, I contributed experimentally to a larger scientific project that investigates of the role of fibroblasts in shaping inflammation and extracellular matrix remodelling in the female reproductive tract during ageing. The results emphasize the contribution of fibroblasts to age-related fibrosis and chronic tissue inflammation. Finally, the last project involved collecting extensive datasets of mouse single cell RNA sequencing and spatial transcriptomics data to provide insights into female reproductive tract ageing after repeated hormonal stimulations, complemented by additional experiments in mouse and human. This research project will have significant implications for understanding the long-term effects of hormonal stimulation on reproductive tissue health and the broader mechanisms of reproductive ageing.
536 _ _ |0 G:(DE-HGF)POF4-312
|a 312 - Funktionelle und strukturelle Genomforschung (POF4-312)
|c POF4-312
|f POF IV
|x 0
856 4 _ |u https://inrepo02.dkfz.de/record/294445/files/Daugelaite_PhD_thesis%20wo%20acknl.pdf
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856 4 _ |u https://inrepo02.dkfz.de/record/294445/files/Daugelaite_PhD_thesis%20wo%20acknl.pdf?subformat=pdfa
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909 C O |o oai:inrepo02.dkfz.de:294445
|p VDB
910 1 _ |0 I:(DE-588b)2036810-0
|6 P:(DE-He78)2a877d9e575a12fba128c39bc22580ec
|a Deutsches Krebsforschungszentrum
|b 0
|k DKFZ
913 1 _ |0 G:(DE-HGF)POF4-312
|1 G:(DE-HGF)POF4-310
|2 G:(DE-HGF)POF4-300
|3 G:(DE-HGF)POF4
|4 G:(DE-HGF)POF
|a DE-HGF
|b Gesundheit
|l Krebsforschung
|v Funktionelle und strukturelle Genomforschung
|x 0
914 1 _ |y 2024
920 1 _ |0 I:(DE-He78)B270-20160331
|k B270
|l B270 Regulatorische Genomik und Evolution von Tumoren
|x 0
980 _ _ |a phd
980 _ _ |a VDB
980 _ _ |a I:(DE-He78)B270-20160331
980 _ _ |a UNRESTRICTED

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