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@ARTICLE{Sala:294463,
      author       = {C. Sala and M. Würtz and E. S. Atorino and A. Neuner and
                      P. J. Partscht$^*$ and T. Hoffmann and S. Eustermann and E.
                      Schiebel},
      title        = {{A}n interaction network of inner centriole proteins
                      organised by {POC}1{A}-{POC}1{B} heterodimer crosslinks
                      ensures centriolar integrity.},
      journal      = {Nature Communications},
      volume       = {15},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DKFZ-2024-02288},
      pages        = {9857},
      year         = {2024},
      note         = {(DKFZ)-ZMBH Allianz},
      abstract     = {Centriole integrity, vital for cilia formation and
                      chromosome segregation, is crucial for human health. The
                      inner scaffold within the centriole lumen composed of the
                      proteins POC1B, POC5 and FAM161A is key to this integrity.
                      Here, we provide an understanding of the function of inner
                      scaffold proteins. We demonstrate the importance of an
                      interaction network organised by POC1A-POC1B heterodimers
                      within the centriole lumen, where the WD40 domain of POC1B
                      localises close to the centriole wall, while the
                      POC5-interacting WD40 of POC1A resides in the centriole
                      lumen. The POC1A-POC5 interaction and POC5 tetramerization
                      are essential for inner scaffold formation and centriole
                      stability. The microtubule binding proteins FAM161A and MDM1
                      by binding to POC1A-POC1B, likely positioning the POC5
                      tetramer near the centriole wall. Disruption of POC1A or
                      POC1B leads to centriole microtubule defects and deletion of
                      both genes causes centriole disintegration. These findings
                      provide insights into organisation and function of the inner
                      scaffold.},
      cin          = {D250},
      ddc          = {500},
      cid          = {I:(DE-He78)D250-20160331},
      pnm          = {314 - Immunologie und Krebs (POF4-314)},
      pid          = {G:(DE-HGF)POF4-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39543170},
      doi          = {10.1038/s41467-024-54247-5},
      url          = {https://inrepo02.dkfz.de/record/294463},
}