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@ARTICLE{SimovicLorenz:294547,
      author       = {M. Simovic-Lorenz$^*$ and A. Ernst$^*$},
      title        = {{C}hromothripsis in cancer.},
      journal      = {Nature reviews / Cancer},
      volume       = {25},
      number       = {2},
      issn         = {1474-175X},
      address      = {London [u.a.]},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2024-02322},
      pages        = {79–92},
      year         = {2025},
      note         = {#EA:B420#LA:B420# / Volume 25 | February 2025 | 79–92},
      abstract     = {Chromothripsis is a mutational phenomenon in which a single
                      catastrophic event generates extensive rearrangements of one
                      or a few chromosomes. This extreme form of genome
                      instability has been detected in $30-50\%$ of cancers.
                      Studies conducted in the past few years have uncovered
                      insights into how chromothripsis arises and deciphered some
                      of the cellular and molecular consequences of chromosome
                      shattering. This Review discusses the defining features of
                      chromothripsis and describes its prevalence across different
                      cancer types as indicated by the manifestations of
                      chromothripsis detected in human cancer samples. The
                      different mechanistic models of chromothripsis, derived from
                      in vitro systems that enable causal inference through
                      experimental manipulation, are discussed in detail. The
                      contribution of chromothripsis to cancer development, the
                      selective advantages that cancer cells might gain from
                      chromothripsis, the evolutionary trajectories of
                      chromothriptic tumours, and the potential vulnerabilities
                      and therapeutic opportunities presented by chromothriptic
                      cells are also highlighted.},
      subtyp        = {Review Article},
      cin          = {B420 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)B420-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39548283},
      doi          = {10.1038/s41568-024-00769-5},
      url          = {https://inrepo02.dkfz.de/record/294547},
}