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000294550 041__ $$aEnglish
000294550 082__ $$a610
000294550 1001_ $$aChen, Zhiyi$$b0
000294550 245__ $$aPRDX6 contributes to selenocysteine metabolism and ferroptosis resistance.
000294550 260__ $$aNew York, NY$$bElsevier$$c2024
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000294550 500__ $$aDKFZ-ZMBH Alliance / 84(23), pp. 4645–4659.e9
000294550 520__ $$aSelenocysteine (Sec) metabolism is crucial for cellular function and ferroptosis prevention and begins with the uptake of the Sec carrier, selenoprotein P (SELENOP). Following uptake, Sec released from SELENOP is metabolized via selenocysteine lyase (SCLY), producing selenide, a substrate for selenophosphate synthetase 2 (SEPHS2), which provides the essential selenium donor, selenophosphate (H2SePO3-), for the biosynthesis of the Sec-tRNA. Here, we discovered an alternative pathway in Sec metabolism mediated by peroxiredoxin 6 (PRDX6), independent of SCLY. Mechanistically, we demonstrate that PRDX6 can readily react with selenide and interact with SEPHS2, potentially acting as a selenium delivery system. Moreover, we demonstrate the functional significance of this alternative route in human cancer cells, revealing a notable association between elevated expression of PRDX6 and human MYCN-amplified neuroblastoma subtype. Our study sheds light on a previously unrecognized aspect of Sec metabolism and its implications in ferroptosis, offering further possibilities for therapeutic exploitation.
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000294550 650_7 $$2Other$$acancer metabolism
000294550 650_7 $$2Other$$acell death
000294550 650_7 $$2Other$$aferroptosis
000294550 650_7 $$2Other$$aneuroblastoma
000294550 650_7 $$2Other$$aselenium
000294550 650_7 $$2Other$$aselenocysteine metabolism
000294550 7001_ $$aInague, Alex$$b1
000294550 7001_ $$0P:(DE-He78)3273a29ccb056de5321a084dec4f94c2$$aKaushal, Kamini$$b2$$udkfz
000294550 7001_ $$aFazeli, Gholamreza$$b3
000294550 7001_ $$0P:(DE-He78)4e0aeb30e4b63dfe6d5b210b766e2c57$$aSchilling, Danny$$b4$$udkfz
000294550 7001_ $$aXavier da Silva, Thamara N$$b5
000294550 7001_ $$aDos Santos, Ancely Ferreira$$b6
000294550 7001_ $$0P:(DE-He78)75a2a95b1b7da2d1781b586960d31967$$aCheytan, Tasneem$$b7$$udkfz
000294550 7001_ $$aFreitas, Florencio Porto$$b8
000294550 7001_ $$aYildiz, Umut$$b9
000294550 7001_ $$aViviani, Lucas Gasparello$$b10
000294550 7001_ $$aLima, Rodrigo Santiago$$b11
000294550 7001_ $$aPinz, Mikaela Peglow$$b12
000294550 7001_ $$aMedeiros, Isadora$$b13
000294550 7001_ $$aIijima, Thais Satie$$b14
000294550 7001_ $$aAlegria, Thiago Geronimo Pires$$b15
000294550 7001_ $$aPereira da Silva, Railmara$$b16
000294550 7001_ $$aDiniz, Larissa Regina$$b17
000294550 7001_ $$aWeinzweig, Simon$$b18
000294550 7001_ $$aKlein-Seetharaman, Judith$$b19
000294550 7001_ $$0P:(DE-He78)732f4fbcddb0042251aa759a2e74d3b2$$aTrumpp, Andreas$$b20$$udkfz
000294550 7001_ $$aMañas, Adriana$$b21
000294550 7001_ $$aHondal, Robert$$b22
000294550 7001_ $$aBartenhagen, Christoph$$b23
000294550 7001_ $$aFischer, Matthias$$b24
000294550 7001_ $$aShimada, Briana K$$b25
000294550 7001_ $$aSeale, Lucia A$$b26
000294550 7001_ $$aChillon, Thilo Samson$$b27
000294550 7001_ $$aFabiano, Marietta$$b28
000294550 7001_ $$aSchomburg, Lutz$$b29
000294550 7001_ $$aSchweizer, Ulrich$$b30
000294550 7001_ $$aNetto, Luis E$$b31
000294550 7001_ $$aMeotti, Flavia C$$b32
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000294550 7001_ $$aMiyamoto, Sayuri$$b35
000294550 7001_ $$aFriedmann Angeli, José Pedro$$b36
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