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000294552 0247_ $$2doi$$a10.1016/j.jbiotec.2024.07.006
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000294552 0247_ $$2ISSN$$a1873-4863
000294552 037__ $$aDKFZ-2024-02327
000294552 041__ $$aEnglish
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000294552 1001_ $$0P:(DE-HGF)0$$aLoghmani, Seyed Babak$$b0$$eFirst author
000294552 245__ $$aComparing genome-scale metabolic models of the non-resistant Enterococcus faecalis ATCC 19433 and the multi-resistant Enterococcus faecalis V583.
000294552 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2024
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000294552 520__ $$aEnterococcus faecalis is a versatile lactic acid bacterium with a large variety of implications for humans. While some strains of this species are pathobionts being resistant against most of the common antibiotics, other strains are regarded as biological protectants or even probiotics. Accordingly, E. faecalis strains largely differ in the size and content of their accessory genome. In this study, we describe the genome-scale metabolic network reconstruction of E. faecalis ATCC 19433, a non-resistant human-associated strain. A comparison of the genome-scale metabolic model (GSM) of E. faecalis ATCC 19433 with a previously published GSM of the multi-resistant pathobiontic E. faecalis V583 reveals high similarities in the central metabolic abilities of these two human associated strains. This is reflected, e.g., in the identical amino acid auxotrophies. The ATCC 19433 strain, however, has a 14.1 % smaller genome than V583 and lacks the multiple antibiotic resistance genes and genes involved in capsule formation. Based on the measured metabolic fluxes at different growth rates, the energy demand at zero growth was calculated to be about 40 % lower for the ATCC 19433 strain compared to V583. Furthermore, the ATCC 19433 strain seems less prone to the depletion of amino acids utilizable for energy metabolism. This might hint at a lower overall energy demand of the ATCC 19433 strain as compared to V583.
000294552 536__ $$0G:(DE-HGF)POF4-312$$a312 - Funktionelle und strukturelle Genomforschung (POF4-312)$$cPOF4-312$$fPOF IV$$x0
000294552 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000294552 650_7 $$2Other$$aAmino acid auxotrophies
000294552 650_7 $$2Other$$aEnergy demand
000294552 650_7 $$2Other$$aEnterococcus faecalis
000294552 650_7 $$2Other$$aGenome-scale metabolic model
000294552 650_7 $$2NLM Chemicals$$aAnti-Bacterial Agents
000294552 650_2 $$2MeSH$$aEnterococcus faecalis: genetics
000294552 650_2 $$2MeSH$$aEnterococcus faecalis: metabolism
000294552 650_2 $$2MeSH$$aGenome, Bacterial: genetics
000294552 650_2 $$2MeSH$$aMetabolic Networks and Pathways: genetics
000294552 650_2 $$2MeSH$$aModels, Biological
000294552 650_2 $$2MeSH$$aDrug Resistance, Multiple, Bacterial: genetics
000294552 650_2 $$2MeSH$$aHumans
000294552 650_2 $$2MeSH$$aAnti-Bacterial Agents: pharmacology
000294552 7001_ $$0P:(DE-HGF)0$$aZitzow, Eric$$b1
000294552 7001_ $$0P:(DE-He78)c0f06b8e8c4978a970ffe6531ded37b2$$aSchwarzmüller, Luisa$$b2$$udkfz
000294552 7001_ $$0P:(DE-HGF)0$$aHumboldt, Yvonne$$b3
000294552 7001_ $$0P:(DE-HGF)0$$aEisenberg, Philip$$b4
000294552 7001_ $$0P:(DE-HGF)0$$aKreikemeyer, Bernd$$b5
000294552 7001_ $$0P:(DE-HGF)0$$aVeith, Nadine$$b6
000294552 7001_ $$0P:(DE-HGF)0$$aKummer, Ursula$$b7
000294552 7001_ $$0P:(DE-HGF)0$$aFiedler, Tomas$$b8$$eCorresponding author
000294552 773__ $$0PERI:(DE-600)2016476-2$$a10.1016/j.jbiotec.2024.07.006$$gVol. 392, p. 109 - 117$$p109 - 117$$tJournal of biotechnology$$v392$$x0168-1656$$y2024
000294552 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a Ruprecht-Karls University Heidelberg, Bioquant, Center for Organismal Studies$$b0
000294552 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a Rostock University Medical Centre, Institute of Medical Microbiology, Virology and Hygiene$$b1
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000294552 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a Rostock University Medical Centre, Institute of Medical Microbiology, Virology and Hygiene$$b8
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