TY  - JOUR
AU  - Loghmani, Seyed Babak
AU  - Zitzow, Eric
AU  - Schwarzmüller, Luisa
AU  - Humboldt, Yvonne
AU  - Eisenberg, Philip
AU  - Kreikemeyer, Bernd
AU  - Veith, Nadine
AU  - Kummer, Ursula
AU  - Fiedler, Tomas
TI  - Comparing genome-scale metabolic models of the non-resistant Enterococcus faecalis ATCC 19433 and the multi-resistant Enterococcus faecalis V583.
JO  - Journal of biotechnology
VL  - 392
SN  - 0168-1656
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2024-02327
SP  - 109 - 117
PY  - 2024
N1  - ISSN 0168-1656 not unique: **2 hits**.
AB  - Enterococcus faecalis is a versatile lactic acid bacterium with a large variety of implications for humans. While some strains of this species are pathobionts being resistant against most of the common antibiotics, other strains are regarded as biological protectants or even probiotics. Accordingly, E. faecalis strains largely differ in the size and content of their accessory genome. In this study, we describe the genome-scale metabolic network reconstruction of E. faecalis ATCC 19433, a non-resistant human-associated strain. A comparison of the genome-scale metabolic model (GSM) of E. faecalis ATCC 19433 with a previously published GSM of the multi-resistant pathobiontic E. faecalis V583 reveals high similarities in the central metabolic abilities of these two human associated strains. This is reflected, e.g., in the identical amino acid auxotrophies. The ATCC 19433 strain, however, has a 14.1 
KW  - Enterococcus faecalis: genetics
KW  - Enterococcus faecalis: metabolism
KW  - Genome, Bacterial: genetics
KW  - Metabolic Networks and Pathways: genetics
KW  - Models, Biological
KW  - Drug Resistance, Multiple, Bacterial: genetics
KW  - Humans
KW  - Anti-Bacterial Agents: pharmacology
KW  - Amino acid auxotrophies (Other)
KW  - Energy demand (Other)
KW  - Enterococcus faecalis (Other)
KW  - Genome-scale metabolic model (Other)
KW  - Anti-Bacterial Agents (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:38996920
DO  - DOI:10.1016/j.jbiotec.2024.07.006
UR  - https://inrepo02.dkfz.de/record/294552
ER  -