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@ARTICLE{Loghmani:294552,
      author       = {S. B. Loghmani and E. Zitzow and L. Schwarzmüller$^*$ and
                      Y. Humboldt and P. Eisenberg and B. Kreikemeyer and N. Veith
                      and U. Kummer and T. Fiedler},
      title        = {{C}omparing genome-scale metabolic models of the
                      non-resistant {E}nterococcus faecalis {ATCC} 19433 and the
                      multi-resistant {E}nterococcus faecalis {V}583.},
      journal      = {Journal of biotechnology},
      volume       = {392},
      issn         = {0168-1656},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2024-02327},
      pages        = {109 - 117},
      year         = {2024},
      note         = {ISSN 0168-1656 not unique: **2 hits**.},
      abstract     = {Enterococcus faecalis is a versatile lactic acid bacterium
                      with a large variety of implications for humans. While some
                      strains of this species are pathobionts being resistant
                      against most of the common antibiotics, other strains are
                      regarded as biological protectants or even probiotics.
                      Accordingly, E. faecalis strains largely differ in the size
                      and content of their accessory genome. In this study, we
                      describe the genome-scale metabolic network reconstruction
                      of E. faecalis ATCC 19433, a non-resistant human-associated
                      strain. A comparison of the genome-scale metabolic model
                      (GSM) of E. faecalis ATCC 19433 with a previously published
                      GSM of the multi-resistant pathobiontic E. faecalis V583
                      reveals high similarities in the central metabolic abilities
                      of these two human associated strains. This is reflected,
                      e.g., in the identical amino acid auxotrophies. The ATCC
                      19433 strain, however, has a 14.1 $\%$ smaller genome than
                      V583 and lacks the multiple antibiotic resistance genes and
                      genes involved in capsule formation. Based on the measured
                      metabolic fluxes at different growth rates, the energy
                      demand at zero growth was calculated to be about 40 $\%$
                      lower for the ATCC 19433 strain compared to V583.
                      Furthermore, the ATCC 19433 strain seems less prone to the
                      depletion of amino acids utilizable for energy metabolism.
                      This might hint at a lower overall energy demand of the ATCC
                      19433 strain as compared to V583.},
      keywords     = {Enterococcus faecalis: genetics / Enterococcus faecalis:
                      metabolism / Genome, Bacterial: genetics / Metabolic
                      Networks and Pathways: genetics / Models, Biological / Drug
                      Resistance, Multiple, Bacterial: genetics / Humans /
                      Anti-Bacterial Agents: pharmacology / Amino acid
                      auxotrophies (Other) / Energy demand (Other) / Enterococcus
                      faecalis (Other) / Genome-scale metabolic model (Other) /
                      Anti-Bacterial Agents (NLM Chemicals)},
      cin          = {B050},
      ddc          = {540},
      cid          = {I:(DE-He78)B050-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38996920},
      doi          = {10.1016/j.jbiotec.2024.07.006},
      url          = {https://inrepo02.dkfz.de/record/294552},
}