%0 Journal Article
%A Berghaus, Natalie
%A Hielscher, Thomas
%A Savran, Dilan
%A Schrimpf, Daniel
%A Maas, Sybren L N
%A Preusser, Matthias
%A Weller, Michael
%A Acker, Till
%A Herold-Mende, Christel
%A Wick, Wolfgang
%A von Deimling, Andreas
%A Sahm, Felix
%T Meningiomas: Sex-Specific Differences and Prognostic Implications of a Chromosome X Loss.
%J Neuro-Oncology
%V 27
%N 4
%@ 1522-8517
%C Oxford
%I Oxford Univ. Press
%M DKFZ-2024-02330
%P 1019-1028
%D 2025
%Z #EA:B300#LA:B300# / 2025 May 15;27(4):1019-1028
%X Meningiomas are the most common primary intracranial tumours in adults. Several studies proposed new stratification systems with a more accurate risk prediction than the WHO grading, e.g. based on methylation and copy number variations (CNVs). Yet, common shortcomings in these analyses are either a lack of stratification by sex of patients or excluding the gonososmes from CNV assessment.Within this study, DNA methylation array data from 7,424 meningioma samples as well as targeted sequencing, clinical annotations and morphology subtyping of 796 samples were examined for differences between females and males regarding mutations, methylation classes, copy number variations and histology.Meningiomas from females accounted for about 53 
%K Copy Number Variations (Other)
%K Meningioma (Other)
%K X chromosome (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39535060
%R 10.1093/neuonc/noae239
%U https://inrepo02.dkfz.de/record/294555